1. Gene
  2. Xdh - xanthine dehydrogenase Gene

Xdh - xanthine dehydrogenase Gene

中文名称:黄嘌呤脱氢酶

种属: Mus musculus

同用名: XO; Xor; Xox1; Xox-1

基因 ID: 22436 | 基因类型: protein coding

关于 Xdh

Chromosome 17: 74,190,890-74,257,191 reverse strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 41 phenotypes. Broad expression in duodenum adult (RPKM 55.7), small intestine adult (RPKM 47.7) and 16 other tissues.

功能概要

该基因编码黄嘌呤脱氢酶蛋白家族的一个成员。编码的蛋白质已被确定为基于其执行机械不同功能的能力的兼职蛋白质。编码的蛋白质以两种不同的酶促形式存在,即黄嘌呤脱氢酶或黄嘌呤氧化酶,并在嘌呤降解中发挥作用。其他研究还表明它在脂肪形成中的作用,以及在哺乳期乳腺的乳脂滴中作为结构蛋白的功能。 [RefSeq 提供,2014 年 1 月]

This gene encodes a member of the xanthine dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein exists as two distinct enzymatic forms, either as xanthine dehydrogenase, or as Xanthine Oxidase, and functions in purine degradation. Additional studies also suggest a role in adipogenesis, and a function as a structural protein in milk fat droplets in the lactating mammary gland. [provided by RefSeq, Jan 2014]

Xdh 基因产物(1)

mRNA Protein Name
NM_011723.3 NP_035853.2 xanthine dehydrogenase/oxidase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hypoxanthine dehydrogenase activity IDA
IDA: 通过直接分析推断
8064675 MGI
enables hypoxanthine dehydrogenase activity IMP
IMP: 通过突变表型推断
30936145 MGI
enables hypoxanthine oxidase activity IDA
IDA: 通过直接分析推断
8064675 MGI
enables hypoxanthine oxidase activity IMP
IMP: 通过突变表型推断
30936145 MGI
enables oxidoreductase activity IDA
IDA: 通过直接分析推断
17597094 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8541302 MGI
enables xanthine dehydrogenase activity IDA
IDA: 通过直接分析推断
1590774 MGI
enables xanthine dehydrogenase activity IMP
IMP: 通过突变表型推断
12502743 MGI
enables xanthine oxidase activity IDA
IDA: 通过直接分析推断
1590774 MGI
enables xanthine oxidase activity IMP
IMP: 通过突变表型推断
12502743 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in AMP catabolic process IDA
IDA: 通过直接分析推断
8064675 MGI
involved in GMP catabolic process IDA
IDA: 通过直接分析推断
8226898 MGI
involved in IMP catabolic process IDA
IDA: 通过直接分析推断
8064675 MGI
involved in adenosine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in adenosine catabolic process IMP
IMP: 通过突变表型推断
12502743 MGI
involved in allantoin metabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in allantoin metabolic process IMP
IMP: 通过突变表型推断
12502743 MGI
involved in amide catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in amide catabolic process IMP
IMP: 通过突变表型推断
12502743 MGI
involved in dAMP catabolic process IDA
IDA: 通过直接分析推断
8064675 MGI
involved in dGMP catabolic process IDA
IDA: 通过直接分析推断
8226898 MGI
involved in deoxyadenosine catabolic process IDA
IDA: 通过直接分析推断
8064675 MGI
involved in deoxyguanosine catabolic process IDA
IDA: 通过直接分析推断
8226898 MGI
involved in deoxyinosine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in deoxyinosine catabolic process IMP
IMP: 通过突变表型推断
12502743 MGI
involved in guanine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in hypoxanthine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in hypoxanthine catabolic process IMP
IMP: 通过突变表型推断
30936145 MGI
involved in inosine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
involved in inosine catabolic process IMP
IMP: 通过突变表型推断
12502743 MGI
acts upstream of or within iron-sulfur cluster assembly IDA
IDA: 通过直接分析推断
17597094 MGI
acts upstream of or within lactation IMP
IMP: 通过突变表型推断
12502743 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: 通过突变表型推断
12502743 MGI
involved in xanthine catabolic process IDA
IDA: 通过直接分析推断
1590774 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
1590774 MGI
is active in cytosol IMP
IMP: 通过突变表型推断
30936145 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
19800018 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Xdh 蛋白结构

PLN02906

PLN02906: cl33596 (25 - 1320)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1335 a.a.
蛋白主名 其他名称

xanthine dehydrogenase/oxidase

xanthine oxidase

xanthine oxidoreductase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Xdh NCBI NCBI:7498