2. Gene
  3. PDZRN3 - PDZ domain containing ring finger 3 Gene

PDZRN3 - PDZ domain containing ring finger 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 PDZ 结构域的无名指 3

种属: Homo sapiens

同用名: LNX3; SEMCAP3; SEMACAP3

基因 ID: 23024 | 基因类型: protein coding

关于 PDZRN3

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:73,382,431-73,624,941 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in ovary (RPKM 21.4), endometrium (RPKM 16.6) and 20 other tissues.

功能概要

该基因编码环型泛素 E3 连接酶 LNX (麻木蛋白-X 的配体) 家族的成员。这种蛋白质可能在血管形态发生和脂肪细胞、成骨细胞和成肌细胞的分化中发挥作用。该蛋白可能被人乳头瘤病毒 E6 蛋白靶向降解。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 12 月]

This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 Ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

PDZRN3 基因产物(5)

mRNA Protein Name
NM_001303139.2 NP_001290068.1 E3 ubiquitin-protein ligase PDZRN3 isoform 2
NM_001303140.2 NP_001290069.1 E3 ubiquitin-protein ligase PDZRN3 isoform 3
NM_001303141.2 NP_001290070.1 E3 ubiquitin-protein ligase PDZRN3 isoform 4
NM_001303142.2 NP_001290071.1 E3 ubiquitin-protein ligase PDZRN3 isoform 5
NM_015009.3 NP_055824.1 E3 ubiquitin-protein ligase PDZRN3 isoform 1

PDZRN3 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (17 - 57)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (101 - 146)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (252 - 335)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (424 - 500)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1066 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase PDZRN3

RING-type E3 ubiquitin transferase PDZRN3

关联疾病

疾病名称 别名
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10307 PDZRN3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PDZRN3 VGNC VGNC:81917
Mus musculus PDZRN3 MGD MGI:1933157
Rattus norvegicus PDZRN3 RGD RGD:1305250
Felis catus PDZRN3 VGNC VGNC:102656
Bos taurus PDZRN3 VGNC VGNC:32731
Macaca mulatta PDZRN3 VGNC VGNC:75820
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z