2. Gene
  3. CDK19 - cyclin dependent kinase 19 Gene

CDK19 - cyclin dependent kinase 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 19

种属: Homo sapiens

同用名: CDK11; DEE87; CDC2L6; EIEE87; bA346C16.3

基因 ID: 23097 | 基因类型: protein coding

关于 CDK19

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,609,978-110,815,855 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues, 26 paralogues and is associated with 3 phenotypes. Broad expression in prostate (RPKM 16.5), brain (RPKM 8.7) and 23 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质是 Mediator 共激活因子复合物的成分之一。 Mediator 复合物是一种多蛋白复合物，是通过 RNA 聚合酶 II 转录的基因的 DNA 结合转录因子进行转录激活所必需的。由该基因编码的蛋白质类似于细胞周期蛋白依赖性激酶 8，它也可以是 Mediator 复合体的一个组成部分。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

CDK19 基因产物(18)

mRNA Protein Name
XM_047418468.1 XP_047274424.1 cyclin-dependent kinase 19 isoform X2
XM_047418471.1 XP_047274427.1 cyclin-dependent kinase 19 isoform X7
NM_001300960.2 NP_001287889.1 cyclin-dependent kinase 19 isoform 2
XM_024446378.2 XP_024302146.1 cyclin-dependent kinase 19 isoform X2
NM_001300964.2 NP_001287893.1 cyclin-dependent kinase 19 isoform 3
NM_015076.5 NP_055891.1 cyclin-dependent kinase 19 isoform 1
XM_047418472.1 XP_047274428.1 cyclin-dependent kinase 19 isoform X7
XM_024446376.2 XP_024302144.2 cyclin-dependent kinase 19 isoform X2
XM_047418467.1 XP_047274423.1 cyclin-dependent kinase 19 isoform X2
XM_047418465.1 XP_047274421.1 cyclin-dependent kinase 19 isoform X1
XM_005266871.4 XP_005266928.1 cyclin-dependent kinase 19 isoform X5
XM_024446380.2 XP_024302148.1 cyclin-dependent kinase 19 isoform X2
XM_047418470.1 XP_047274426.1 cyclin-dependent kinase 19 isoform X6
XM_011535630.3 XP_011533932.2 cyclin-dependent kinase 19 isoform X4
NM_001300963.2 NP_001287892.1 cyclin-dependent kinase 19 isoform 3
XM_024446377.2 XP_024302145.1 cyclin-dependent kinase 19 isoform X2
XM_047418473.1 XP_047274429.1 cyclin-dependent kinase 19 isoform X8
XM_047418469.1 XP_047274425.1 cyclin-dependent kinase 19 isoform X3

CDK19 蛋白结构

Pkinase

Pkinase: Protein kinase domain (26 - 335)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 19

CDC2-related protein kinase 6

CDK8-like cyclin-dependent kinase

cell division cycle 2-like 6 (CDK8-like)

cell division cycle 2-like protein kinase 6

cell division protein kinase 19

cyclin-dependent kinase (CDC2-like) 11

cyclin-dependent kinase 11

death-preventing kinase

关联疾病

疾病名称 别名
Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy

Non-Specific Eoee

Undetermined Eoee
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Developmental And Epileptic Encephalopathy 87

DEE87

Epileptic Encephalopathy, Early Infantile, 87

Eiee87

Developmental And Epileptic Encephalopathy, 87

Early Infantile Epileptic Encephalopathy 87
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Ohdo Syndrome

Young Simpson Syndrome

Ohdo Blepharophimosis Syndrome

Blepharophimosis Syndrome Ohdo Type

Blepharophimosis Intellectual Disability Syndromes

Bmrs

Blepharophimosis-Intellectual Disability Syndrome

Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth

Blepharophimosis Mental Retardation Syndromes

Sbbys Syndrome

Say Barber Biesecker Young-Simpson Syndrome

Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type

Bmrs, Ohdo Type

Blepharophimosis Syndrome, Ohdo Type

Ohdo-Madokoro-Sonoda Syndrome

Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type

Blepharophimosis - Intellectual Disability Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126675A AS2863619 Inhibitor 99.94% 否
HY-111388A SEL120-34A monohydrochloride Inhibitor 99.29% 否
HY-19984 CCT-251921 Inhibitor 99.01% 否
HY-15681 Senexin A Inhibitor 99.79% 否
HY-122586 BRD6989 Inhibitor 99.56% 否
HY-111388B SEL120-34A hydrochloride Inhibitor 99.98% 否
HY-126675 AS2863619 free base Inhibitor 99.87% 否
HY-139875 JH-XVI-178 Inhibitor 98.16% 否
HY-101800 Senexin B Inhibitor 99.72% 否
HY-143889 Senexin C Inhibitor 98.82% 否
HY-111427 CDK8/19-IN-1 Inhibitor 98.03% 否
HY-111388 SEL120-34A Inhibitor / 否
HY-15681A Senexin A hydrochloride Inhibitor / 否
HY-D2311 CDK19 Probe 1 / 否
HY-158377 CDK8/19-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus CDK19 VGNC VGNC:27122
Mus musculus CDK19 MGD MGI:1925584
Canis familiaris CDK19 VGNC VGNC:39050
Macaca mulatta CDK19 VGNC VGNC:71036
Rattus norvegicus CDK19 RGD RGD:1305435
Felis catus CDK19 VGNC VGNC:102398
Others CDK19 NCBI
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