2. Gene
  3. Fcgr4 - Fc receptor, IgG, low affinity IV Gene

Fcgr4 - Fc receptor, IgG, low affinity IV Gene

  • 基因
  • 蛋白

种属: Mus musculus

同用名: Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik

基因 ID: 246256 | 基因类型: protein coding

关于 Fcgr4

功能概要

Enables IgE receptor activity and IgG receptor activity. Involved in neutrophil activation and positive regulation of bone resorption. Located in cell surface. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); hematologic Cancer (multiple); and immunodeficiency 20. Orthologous to human FCGR3A (Fc fragment of IgG receptor IIIa) and FCGR3B (Fc fragment of IgG receptor IIIb). [provided by Alliance of Genome Resources, Apr 2022]

Fcgr4 基因产物(1)

mRNA Protein Name
NM_144559.2 NP_653142.2 low affinity immunoglobulin gamma Fc region receptor III-A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables IgE receptor activity IDA
IDA: 通过直接分析推断
17558411 MGI
enables IgG receptor activity IDA
IDA: 通过直接分析推断
16039578 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: 通过直接分析推断
28389502 MGI
involved in dendritic cell antigen processing and presentation IMP
IMP: 通过突变表型推断
28389502 MGI
involved in neutrophil activation IMP
IMP: 通过突变表型推断
18097064 MGI
involved in positive regulation of bone resorption IMP
IMP: 通过突变表型推断
25824719 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
17558411 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
28389502 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low affinity immunoglobulin gamma Fc region receptor III-A

Fc fragment of IgG, low affinity IIIa, receptor for (CD16)

Fc fragment of IgG, low affinity III, receptor for (CD16)

Fc gammaRIV

Fc receptor-like 3

IgG Fc receptor III-A

low affinity immunoglobulin gamma Fc region receptor IV

重组 Fcgr4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76916 FcgR4/CD16-2 Protein, Mouse (HEK293, His-Avi) A0A0B4J1G0 (Q19-Q203) ≥95%
HY-P76917 FcgR4/CD16-2 Protein, Mouse (Biotinylated, HEK293, His-Avi) A0A0B4J1G0 (Q19-Q203) ≥95%
HY-P76918 FcgR4/CD16-2 Protein, Mouse (HEK293, His) A0A0B4J1G0 (Q19-Q203) ≥95%
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