2. Gene
  3. Cckar - cholecystokinin A receptor Gene

Cckar - cholecystokinin A receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：胆囊收缩素A受体

种属: Rattus norvegicus

同用名: Cck-ar

基因 ID: 24889 | 基因类型: protein coding

关于 Cckar

Primary_assembly 14: 57,292,397-57,300,747 forward strand.mRatBN7.2:CM026987.1

This gene has 1 transcript (splice variant), 202 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 12.6), Liver (RPKM 3.7) and 4 other tissues.

功能概要

该基因编码的蛋白可启动胆囊收缩素受体活性。参与多个过程，包括生长抑素分泌的正调节；因饮食过量而减少食物摄入量；和调节金属离子传输。位于多种细胞成分中，包括核内体；溶酶体；和终端按钮。用于研究肥胖和 2 型糖尿病。胰腺癌的生物标志物。该基因的人类直系同源物与肥胖有关。与人 CCKAR（胆囊收缩素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Cholecystokinin Receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in several cellular components, including endosome; lysosome; and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic Cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar 基因产物(1)

mRNA Protein Name
NM_012688.3 NP_036820.1 cholecystokinin receptor type A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholecystokinin receptor activity IDA
IDA: 通过直接分析推断
18776046 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
10403848 RGD
involved in cellular response to hormone stimulus IEP
IEP: 通过表达模式推断
12649564 RGD
involved in eating behavior IMP
IMP: 通过突变表型推断
16728725 RGD
involved in feeding behavior IDA
IDA: 通过直接分析推断
12414437 RGD
involved in gastric acid secretion IDA
IDA: 通过直接分析推断
9773935 RGD
involved in insulin secretion IDA
IDA: 通过直接分析推断
9773935 RGD
involved in pancreas development IEP
IEP: 通过表达模式推断
10403848 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
18776046 RGD
involved in positive regulation of somatostatin secretion IMP
IMP: 通过突变表型推断
19959964 RGD
involved in reduction of food intake in response to dietary excess IMP
IMP: 通过突变表型推断
12840200 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
11207382 RGD
involved in regulation of potassium ion transport IDA
IDA: 通过直接分析推断
12427859 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
7977738 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17622698 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
15127944 RGD
involved in response to starvation IMP
IMP: 通过突变表型推断
12954406 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
16786113 RGD
involved in temperature homeostasis IMP
IMP: 通过突变表型推断
15178543 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
9169450 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
3408996 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cckar 蛋白结构

CholecysA-Rec_N

CholecysA-Rec_N: pfam09193 (15 - 61)

7tm_GPCRs

7tm_GPCRs: cl28897 (56 - 396)

7tm_GPCRs

7tm_GPCRs: cd14964 (58 - 82)

7tm_GPCRs

7tm_GPCRs: cd14964 (91 - 113)

7tm_GPCRs

7tm_GPCRs: cd14964 (129 - 151)

7tm_GPCRs

7tm_GPCRs: cd14964 (174 - 190)

7tm_GPCRs

7tm_GPCRs: cd14964 (221 - 244)

7tm_GPCRs

7tm_GPCRs: cd14964 (327 - 349)

7tm_GPCRs

7tm_GPCRs: cd14964 (364 - 389)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
蛋白主名 其他名称

cholecystokinin receptor type A

CCK-A receptor

CCK1-R

cholecystokinin-1 receptor

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1096 A71623 Agonist 99.90% 否
HY-B2154 Loxiglumide Antagonist ≥98.0% 否
HY-129810 PD 135158 Antagonist / 否
HY-123434 PD-149164 Agonist / 否
HY-119127 TP-680 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cckar NCBI NCBI:886
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z