2. GPCR/G Protein Neuronal Signaling
  3. Cholecystokinin Receptor
  4. A71623

A71623 是一种有效且高度选择性的 CCK-A 激动剂。A-71623 对 CCK-A 和 CCK-B 的 IC50 分别为 3.7 nM 和 4500 nM。

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Custom Peptide Synthesis

A71623 Chemical Structure

A71623 Chemical Structure

CAS No. : 130408-77-4

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规格 价格 是否有货 数量
1 mg ￥2950
In-stock
5 mg 现货 询价
10 mg   询价  
50 mg   询价  

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Customer Review

A71623 相关抗体

Top Publications Citing Use of Products

查看 Cholecystokinin Receptor 亚型特异性产品:

查看所有亚型
CCKAR CCKBR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively[1].

IC50 & Target

CCKAR

 

体外研究
(In Vitro)

In guinea pig gastric glands, the affinities of A-71623 for the cholecystokinin (CCK)-B/gastrin receptor were 11 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

A71623 相关抗体:
体内研究
(In Vivo)

A71623 (A-63387; i.c.v., but not i.p., injections) reduces food intakes and suppresses intakes of a liquid diet in both deprived and sated rats[2].
A71623 dampens Purkinje neuron pathology and associates deficits in motor performance in Pcp2-ATXN1[30Q]D776;Cck-/- and Pcp2-AXTN1[82Q] mice[3].
A71623 improves motor performance of Pcp2-ATXN2[127Q] SCA2 mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male, Sprague-Dawley rats[2]
Dosage: 5 μL
Administration: Intracerebroventricular (i.c.v) administration, A-71623 was infused using a 28 gauge injection cannula in a volume of 5uL over 60 s
Result: Reduced food intakes and suppressed intakes of a liquid diet.
Animal Model: ATXN1[30Q]-D776, ATXN1[82Q]-D776, ATXN2[127Q], and WT/FVB/NJ mice [3]
Dosage: 0.02 mg/kg/day
Administration: Osmotic minipumps containing either A71623 (0.02mg/kg/day) were implanted intraperitoneally (i.p.)
Result: Treatment dampened Purkinje neuron pathology in ATXN1[30Q]D776;Cck-/- mice and ATXN1[82Q] mice.
Improved motor performance in ATXN2[127Q] mice.
分子量

840.96

Formula

C44H56N8O9
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (59.46 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1891 mL 5.9456 mL 11.8912 mL
5 mM 0.2378 mL 1.1891 mL 2.3782 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.90%

COA (295 KB) LCMS (265 KB)

产品使用指南 (1538 KB)
参考文献

A71623 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1891 mL 5.9456 mL 11.8912 mL 29.7279 mL
5 mM 0.2378 mL 1.1891 mL 2.3782 mL 5.9456 mL
10 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
15 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.9819 mL
20 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
25 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
30 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
40 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
50 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5946 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A71623130408-77-4A 71623A-71623Cholecystokinin ReceptorCCK ReceptorCCKApancreaticamylasephosphoinositidebreakdownfoodintakeInhibitorinhibitorinhibit

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产品名称：
A71623
目录号：
HY-P1096
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