CCKAR

The Cholecystokinin A receptor is a human protein, also known as CCKAR or CCK1. The CCK1R has high affinity for cholecystokinin (CCK) and related peptides that are sulfated on a tyrosine in the 7th position from the COOH terminus with a low affinity for gastrin. In humans, the results of numerous studies support a role for CCK1R in regulation of a variety of physiological processes including gallbladder contraction, sphincter of Oddi relaxation, stimulation of pancreatic secretion, inhibition of acid secretion, relaxation of lower esophageal sphincter tone, slowing of colonic motility and regulation of satiety.