Insr - insulin receptor Gene

中文名称：胰岛素受体

种属: Rattus norvegicus

关于 Insr

功能概要

该基因编码的蛋白可启动多种功能，包括酶结合活性；胰岛素结合活性；和胰岛素受体底物结合活性。参与多个过程，包括动物器官发育；神经元投射组织；和葡萄糖代谢过程的调节。位于几种细胞成分中，包括树突膜；神经细胞体膜；和蛋黄。与树突和神经细胞体共定位。用于研究慢性肾病；糖尿病性神经病变；脂肪肝（多发性）；肝细胞癌；和 2 型糖尿病。多种疾病的生物标志物，包括糖尿病（多种）；脂肪肝（多发性）；肝性脑病;肝细胞癌；和短肠综合症。该基因的人类直系同源物与 Donohue 综合征有关；糖尿病（多发性）；家族性高胰岛素血症性低血糖 5；和生殖器官癌（多发性）。与人类 INSR（胰岛素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Enzyme binding activity; Insulin binding activity; and Insulin Receptor substrate binding activity. Involved in several processes, including animal organ development; neuron projection organization; and regulation of glucose metabolic process. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and yolk. Colocalizes with dendrite and neuronal cell body. Used to study chronic kidney disease; diabetic neuropathy; fatty liver disease (multiple); hepatocellular carcinoma; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); fatty liver disease (multiple); hepatic encephalopathy; hepatocellular carcinoma; and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ Cancer (multiple). Orthologous to human INSR (Insulin Receptor). [provided by Alliance of Genome Resources, Apr 2022]