1. Gene
  2. IPMK - inositol polyphosphate multikinase Gene

IPMK - inositol polyphosphate multikinase Gene

中文名称:肌醇多磷酸多激酶

种属: Homo sapiens

基因 ID: 253430 | 基因类型: protein coding

关于 IPMK

Cytogenetic location: 10q21.1 Genomic coordinates (GRCh38): 10:58,191,517-58,267,894 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 5.2), small intestine (RPKM 4.9) and 25 other tissues.

功能概要

该基因编码肌醇磷酸激酶家族的一个成员。编码的蛋白质对磷酸化肌醇底物具有 3 激酶、5 激酶和 6 激酶活性。所编码的蛋白在肌醇 1,3,4,5,6-五磷酸的生物合成中起重要作用,具有优选的 5-激酶活性。该基因可能在核 mRNA 输出中发挥作用。该基因的假基因位于 13 号染色体的长臂和 19 号染色体的短臂上。[RefSeq 提供,2010 年 12 月]

This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

IPMK 基因产物(1)

mRNA Protein Name
NM_152230.5 NP_689416.1 inositol polyphosphate multikinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables flavonoid binding IDA
IDA: 通过直接分析推断
30624931 GOA
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity IMP
IMP: 通过突变表型推断
29883610 GOA
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
IDA: 通过直接分析推断
30624931 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inositol trisphosphate metabolic process IDA
IDA: 通过直接分析推断
30624931 GOA
involved in necroptotic process IMP
IMP: 通过突变表型推断
29883610 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IPMK 蛋白结构

IPK

IPK: Inositol polyphosphate kinase (127 - 410)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

inositol polyphosphate multikinase

inositol 1,3,4,6-tetrakisphosphate 5-kinase

IPMK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra IPMK Q8NFU5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra IPMK Q8NFU5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hereditary Neuroendocrine Tumor Of Small Intestine

Hereditary Neuroendocrine Tumor Of Small Bowel

Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus IPMK MGD MGI:1916968
Bos taurus IPMK VGNC VGNC:30240
Macaca mulatta IPMK VGNC VGNC:106064
Rattus norvegicus IPMK RGD RGD:620954