2. Gene
  3. Sirpa - signal-regulatory protein alpha Gene

Sirpa - signal-regulatory protein alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Bit; Ptpns1; SHPS-1

基因 ID: 25528 | 基因类型: protein coding

关于 Sirpa

功能概要

Enables GTPase regulator activity; Enzyme binding activity; and protein binding activity involved in heterotypic cell-cell adhesion. Involved in several processes, including cellular response to cytokine stimulus; monocyte extravasation; and regulation of cytokine production. Located in cell surface. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Sirpa 基因产物(1)

mRNA Protein Name
NM_013016.3 NP_037148.3 tyrosine-protein phosphatase non-receptor type substrate 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase regulator activity IMP
IMP: 通过突变表型推断
16055727 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8810330 RGD
enables protein binding involved in heterotypic cell-cell adhesion IPI
IPI: 通过物理相互作用推断
16055727 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
16055727 RGD
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
16055727 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IDA
IDA: 通过直接分析推断
12023387 RGD
involved in cellular response to hydrogen peroxide IMP
IMP: 通过突变表型推断
16055727 RGD
involved in cellular response to interleukin-1 IMP
IMP: 通过突变表型推断
12023387 RGD
involved in cellular response to type II interferon IMP
IMP: 通过突变表型推断
12023387 RGD
involved in monocyte extravasation IMP
IMP: 通过突变表型推断
12023387 RGD
involved in negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
21401967 RGD
involved in regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
16055727 RGD
involved in regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
16055727 RGD
involved in regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
16055727 RGD
involved in regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16055727 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
21401967 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type substrate 1

Brain immunoglobulin like protein with tyrosine - based activation motifs

CD172 antigen-like family member A

Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1)

SHP substrate 1

brain Ig-like molecule with tyrosine-based activ

重组 Sirpa 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76072 SIRP alpha/CD172a Protein, Rat (HEK293, Fc) BAA20368.1 (K32-N373) ≥95%
HY-P76073 SIRP alpha/CD172a Protein, Rat (HEK293, His) P97710 (K32-N373) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12932 SIRPA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirpa NCBI NCBI:140885
Macaca fascicularis Sirpa NCBI NCBI:101926317
Mus musculus Sirpa NCBI NCBI:19261
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