2. Gene
  3. SIRPA - signal regulatory protein alpha Gene

SIRPA - signal regulatory protein alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号调节蛋白α

种属: Homo sapiens

同用名: BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1

基因 ID: 140885 | 基因类型: protein coding

关于 SIRPA

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,894,167-1,940,592 (from NCBI)

This gene has 4 transcripts (splice variants), 290 orthologues, 4 paralogues and is associated with 60 phenotypes. Ubiquitous expression in brain (RPKM 71.2), appendix (RPKM 27.2) and 23 other tissues.

功能概要

该基因编码的蛋白质是信号调节蛋白 (SIRP) 家族的一员，也属于免疫球蛋白超家族。 SIRP 家族成员是受体型跨膜糖蛋白，已知参与受体酪氨酸激酶偶联信号传导过程的负调节。这种蛋白质可以被酪氨酸激酶磷酸化。该 PTP 的磷酸酪氨酸残基已显示可募集含有酪氨酸磷酸酶 (PTP) 的 SH2 结构域，并用作 PTP 的底物。发现该蛋白质参与由各种生长因子受体介导的信号转导。 CD47 已被证明是该受体蛋白的配体。该基因及其产物与 SIRP 家族的其他几个成员具有非常高的相似性。这些相关基因位于染色体 20p13 上彼此非常接近。已经确定了该基因的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several Other members of the SIRP family. These related genes are located in close proximity to each Other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

SIRPA 基因产物(4)

mRNA Protein Name
NM_001040022.1 NP_001035111.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001040023.2 NP_001035112.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001330728.1 NP_001317657.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_080792.3 NP_542970.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell-cell adhesion mediator activity IPI
IPI: 通过物理相互作用推断
11509594 GOA
enables protein antigen binding IPI
IPI: 通过物理相互作用推断
24026300 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17070842 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to interleukin-12 IMP
IMP: 通过突变表型推断
11509594 GOA
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
24026300 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
24511121 GOA
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
11509594 GOA
involved in regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
11509594 GOA
involved in regulation of type II interferon production IMP
IMP: 通过突变表型推断
11509594 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
11509594 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
24026300 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIRPA 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (35 - 144)

C1-set

C1-set: Immunoglobulin C1-set domain (161 - 236)

C1-set

C1-set: Immunoglobulin C1-set domain (262 - 339)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type substrate 1

CD172 antigen-like family member A

SIRPA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIRPA P78324 CD47 Homo sapiens Q08722
Anti Tag CoIP
33961781
种属内
SIRPA P78324 CD47 Homo sapiens Q08722
ELISA
17070842
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SIRPA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7405 SIRP alpha/CD172a Protein, Human (HEK293, His-Myc) P78324-1 (E31-R370) ≥95%
HY-P7406 SIRP alpha/CD172a Protein, Human (HEK293, Fc) P78324-1 (E31-R370) ≥95%
HY-P70484 SIRP alpha/CD172a Protein, Human (CAA71403, HEK293, His) CAA71403.1 (E31-R370) ≥95%
HY-P72412 SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324-1 (E31-R370) ≥95%
HY-P74546 SIRP alpha/CD172a Protein, Human (G75A, HEK293, His) P78324-1 (E31-R370, G75A) ≥95%
HY-P76068 SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, His) AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P76069 SIRP alpha V8/CD172a Protein, Human (AAH38510, HEK293, Fc) AAH38510.1 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P77842 SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi) AAH38510.1 (E31-R369, H54L) ≥95%
HY-P77843 SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H) ≥95%
HY-P77844 SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324-1 (E31-R370, E33G, L44S, T50S, T52I, R54H) ≥95%
HY-P77846 SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) P78324-1 (E31-R370, S105P) ≥95%
HY-P77847 SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi) ATD50864.1 (E31-R369, S44L, S50T, I52T, H54R, V57A) ≥95%
HY-P77836 SIRP alpha V2/CD172a Protein, Human (HEK293, His) AAH26692.1 (E31-R369) ≥95%
HY-P77837 SIRP alpha V2/CD172a Protein, Human (HEK293, Fc) AAH26692.1 (E31-R369) ≥95%
HY-P77840 SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) AAH26692.1 (E31-R369) ≥95%
HY-P77841 SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi) AAH38510.1 (E31-R369, H54L) ≥95%
HY-P77845 SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi) P78324-1 (E31-R370, S105P) ≥95%
HY-P78211 SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) P78324-1 (E31-R370) ≥95%

SIRPA 抗体

目录号 产品名 应用 反应物种
HY-P81616 SIRP alpha Antibody (YA1361) WB, FC Human

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath

Giant Cell Tumor Of Tendon Sheath

Giant Cell Tumor Of Tenosynovium

Giant Cell Tumour Of Tendon Sheath

Giant Cell Tumour Of Tenosynovium

Tenosynovial Giant Cell Tumour

Diffuse-Type Gct

Diffuse-Type Giant Cell Tumor

Pigmented Villonodular Synovitis

Tgct

Tsgct
Refractory Plasma Cell Neoplasm
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12932 SIRPA Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990555 BI-765063 Inhibitor / 否
HY-P990723 Timdarpacept Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIRPA MGD MGI:108563
Rattus norvegicus SIRPA RGD RGD:3449
Macaca fascicularis SIRPA NCBI NCBI:101926317
Others SIRPA NCBI
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