2. Gene
  3. Sirpa - signal-regulatory protein alpha Gene

Sirpa - signal-regulatory protein alpha Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2

基因 ID: 19261 | 基因类型: protein coding

关于 Sirpa

功能概要

Enables protein Phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of MAPK cascade; negative regulation of cytokine production; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Sirpa 基因产物(8)

mRNA Protein Name
NM_001177647.2 NP_001171118.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor
NM_001291019.1 NP_001277948.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor
NM_001291020.1 NP_001277949.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor
NM_001291021.1 NP_001277950.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor
NM_001291022.1 NP_001277951.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor
NM_001355158.1 NP_001342087.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
NM_001355160.1 NP_001342089.1 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6
NM_007547.4 NP_031573.2 tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11895767 MGI
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
17954568 MGI
enables protein phosphorylated amino acid binding IPI
IPI: 通过物理相互作用推断
12393607 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
11118207 MGI
acts upstream of or within cell motility IMP
IMP: 通过突变表型推断
11118207 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: 通过突变表型推断
11118207 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
17954568 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: 通过突变表型推断
11118207 MGI
involved in granulocyte migration IGI
IGI: 通过遗传相互作用推断
24026300 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: 通过突变表型推断
24029230 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of I-kappaB phosphorylation IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of JNK cascade IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of chemokine (C-C motif) ligand 5 production IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of cytokine production involved in inflammatory response IGI
IGI: 通过遗传相互作用推断
23562609 MGI
involved in negative regulation of cytokine production involved in inflammatory response IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of interferon-beta production IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of macrophage inflammatory protein 1 alpha production IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of phagocytosis IMP
IMP: 通过突变表型推断
21401967 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
17954568 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
17954568 MGI
acts upstream of or within phagocytosis, engulfment IDA
IDA: 通过直接分析推断
14634079 MGI
acts upstream of or within phagocytosis, recognition IDA
IDA: 通过直接分析推断
14634079 MGI
acts upstream of or within positive regulation of phagocytosis IDA
IDA: 通过直接分析推断
14634079 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
14634079 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type substrate 1

CD172 antigen-like family member A

SHP substrate 1

brain Ig-like molecule with tyrosine-based activation motifs

brain immunological-like with tyrosine-based motifs

inhibitory receptor SHPS-1

mSIRP-alpha1

myD-1 antigen

protein tyrosine phosphatase,

重组 Sirpa 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72468 SIRP alpha/CD172a Protein, Mouse (HEK293, His) P97797-1/Q6P6I8/BAA13520.1 (K32-N373) ≥95%
HY-P76071 SIRP alpha/CD172a Protein, Mouse (BAA20376, HEK293, Fc) BAA20376.1 (T32-N373) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12932 SIRPA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirpa NCBI NCBI:140885
Macaca fascicularis Sirpa NCBI NCBI:101926317
Rattus norvegicus Sirpa NCBI NCBI:25528
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