2. Gene
  3. EPGN - epithelial mitogen Gene

EPGN - epithelial mitogen Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：上皮有丝分裂原

种属: Homo sapiens

同用名: EPG; PRO9904; ALGV3072

基因 ID: 255324 | 基因类型: protein coding

关于 EPGN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,308,470-74,316,789 (from NCBI)

This gene has 9 transcripts (splice variants), 110 orthologues and 5 paralogues. Restricted expression toward esophagus (RPKM 11.2).

功能概要

该基因编码的蛋白质是表皮生长因子家族的一员。该家族的成员是表皮生长因子受体的配体，在细胞存活、增殖和迁移中发挥作用。据报道，该蛋白质具有高促有丝分裂活性，但对其受体的亲和力低。已经在乳腺癌、膀胱癌和前列腺癌标本中报道了这种转录物和蛋白质的表达。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in Cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

EPGN 基因产物(6)

mRNA Protein Name
NM_001013442.2 NP_001013460.1 epigen isoform 6 precursor
NM_001270989.2 NP_001257918.1 epigen isoform 1 precursor
NM_001270990.2 NP_001257919.1 epigen isoform 2 precursor
NM_001270991.2 NP_001257920.1 epigen isoform 3 precursor
NM_001270992.2 NP_001257921.1 epigen isoform 4 precursor
NM_001270993.2 NP_001257922.1 epigen isoform 5 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor receptor binding IPI
IPI: 通过物理相互作用推断
15611079 GOA
enables growth factor activity IDA
IDA: 通过直接分析推断
15611079 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28988771 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IDA
IDA: 通过直接分析推断
15611079 GOA
involved in epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
15611079 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15611079 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15611079 GOA
involved in positive regulation of mitotic nuclear division IDA
IDA: 通过直接分析推断
15611079 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
15611079 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

epigen

epithelial mitogen homolog

重组 EPGN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7010 Epigen Protein, Human Q6UW88-2 (A24-A95) ≥95%
HY-P7010A Epigen Protein, Human (CHO) Q6UW88-2 (A24-A104) ≥95%

关联疾病

疾病名称 别名
Vallecula Cancer

Malignant Tumor Of Vallecula
Bronchiectasis 2
Proliferative Glomerulonephritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04423 EPGN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EPGN RGD RGD:1560084
Bos taurus EPGN VGNC VGNC:53711
Felis catus EPGN VGNC VGNC:107331
Mus musculus EPGN MGD MGI:1919170
Canis familiaris EPGN VGNC VGNC:40403
Macaca mulatta EPGN VGNC VGNC:72061
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