NPB - neuropeptide B Gene

中文名称：神经肽 B

种属: Homo sapiens

同用名: L7; PPL7; PPNPB

基因 ID: 256933 | 基因类型: protein coding

关于 NPB

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,902,238-81,902,905 (from NCBI)

This gene has 2 transcripts (splice variants), 220 orthologues and 1 paralogue. Biased expression in kidney (RPKM 3.4), fat (RPKM 2.9) and 12 other tissues.

功能概要

该基因编码神经肽 B/W 蛋白质家族和前原蛋白的成员，后者经过蛋白水解处理可产生多种蛋白质产物。编码产物包括神经肽 B-23 和 C 末端延伸形式神经肽 B-29，其特征在于 N 末端溴化色氨酸氨基酸。与相关的 NPB/W 受体 2 相比，这两种编码的肽都以更高的亲和力与神经肽 B/W (NPB/W) 受体 1 结合。这些肽可以调节啮齿动物的进食、痛觉和压力。[RefSeq 提供，2015 年 7 月]

This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded Peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These Peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015]

NPB 基因产物(1)

mRNA	Protein	Name
NM_148896.5	NP_683694.1	neuropeptide B preproprotein

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12118011	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	12118011	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPB 蛋白结构

NPBW

0
100
125 a.a.

蛋白主名

其他名称

neuropeptide B

prepro-NPB

重组 NPB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71449	Neuropeptide B Protein, Human (GST)	Q8NG41 (W25-A53)	≥95%

关联疾病

疾病名称

别名

Niemann-Pick Disease, Type B

Niemann-Pick Disease Type B	Acid Sphingomyelinase Deficiency, Visceral Type
Asmd, Visceral Type	Niemann Pick Disease Type B
Chronic Visceral Acid Sphingomyelinase Deficiency	Chronic Visceral Asmd
Npd-B	Niemann-Pick Disease B
NPDB	Niemann-Pick Disease Adult Non-Neuronopathic Form
Niemann-Pick Disease Intermediate With Visceral Involvement And Rapid Progression	Niemann-Pick Disease Type E
Niemann-Pick Disease Type F	Niemann-Pick Disease Type I
Niemann-Pick Disease Visceral Form	Npb
Sphingomyelinase Deficiency	Sphingomyelin Lipidosis
Niemann-Picks Disease Type B	Niemann-Pick Disease, Type E
Niemann-Pick Diseases	Niemann-Pick Disease, Type A

Gallbladder Papillomatosis

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Niemann-Pick Disease, Type A

Niemann-Pick Disease Type A	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency	Niemann-Pick Disease, Intermediate, Protracted Neurovisceral
Acid Sphingomyelinase Deficiency, Neurovisceral Type	Asmd, Neurovisceral Type
Infantile Neurovisceral Acid Sphingomyelinase Deficiency	Infantile Neurovisceral Asmd
Npd-A	Niemann-Pick Disease A
NPDA	Classical Niemann-Pick Disease
Niemann-Pick Disease Acute Neuronopathic Form	Niemann-Pick Disease Acute Neurovisceral Form
Niemann-Pick Disease Classical Infantile Form	Niemann-Pick Disease Intermediate Protracted Neurovisceral
Niemann-Pick Disease Neuronopathic Type	Niemann-Pick Disease Type I
Npa	Niemann-Pick Diseases

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-119368	NPB	Inhibitor	≥98.0%	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09473	NPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NPB	VGNC	VGNC:43911
Mus musculus	NPB	MGD	MGI:2387153
Felis catus	NPB	VGNC	VGNC:99307
Macaca mulatta	NPB	VGNC	VGNC:75286
Rattus norvegicus	NPB	RGD	RGD:708513
Bos taurus	NPB	VGNC	VGNC:32192
Others	NPB	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NPB - neuropeptide B Gene

关于 NPB

功能概要

NPB 基因产物(1)

NPB 蛋白结构

重组 NPB 蛋白

关联疾病

直系同源

热门区域

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NPB - neuropeptide B Gene

关于 NPB

功能概要

NPB 基因产物(1)

NPB 蛋白结构

重组 NPB 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z