2. Gene
  3. Ctsl - cathepsin L Gene

Ctsl - cathepsin L Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组织蛋白酶 L

种属: Rattus norvegicus

同用名: CatL; CATHL; Ctsl1

基因 ID: 25697 | 基因类型: protein coding

关于 Ctsl

Primary_assembly 17: 764,309-770,548 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 711 orthologues, 27 paralogues and is associated with 26 phenotypes. Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues.

功能概要

该基因编码的蛋白可启动激肽原结合活性；肽酶活性；和肽结合活性。参与多个过程，包括自噬性细胞死亡；生殖结构发育；以及对气味的反应。位于多个细胞成分中，包括质膜的外侧；微绒毛;和周核体。与细胞和分泌颗粒的顶端部分共定位。用于研究肝细胞癌。多种疾病的生物标志物，包括脑缺血；甲状腺功能亢进症;肌肉萎缩;中耳炎;和胰腺炎。该基因的人类直系同源物与肥厚性心肌病有关。与包括 CTSV（组织蛋白酶 V）在内的几种人类基因同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (Cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]

Ctsl 基因产物(1)

mRNA Protein Name
NM_013156.2 NP_037288.1 procathepsin L preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity IDA
IDA: 通过直接分析推断
8702598 RGD
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
12788072 RGD
enables kininogen binding IPI
IPI: 通过物理相互作用推断
3356189 RGD
enables peptide binding IDA
IDA: 通过直接分析推断
8702598 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
2470410 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Sertoli cell differentiation IEP
IEP: 通过表达模式推断
15647457 RGD
involved in autophagic cell death IEP
IEP: 通过表达模式推断
16176344 RGD
involved in cellular response to starvation IEP
IEP: 通过表达模式推断
16176344 RGD
involved in decidualization IEP
IEP: 通过表达模式推断
15644143 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
16135663 RGD
involved in nerve development IEP
IEP: 通过表达模式推断
15686940 RGD
involved in protein catabolic process IDA
IDA: 通过直接分析推断
11788364 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
12788072 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
15705658 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
9877467 RGD
involved in response to gonadotropin IEP
IEP: 通过表达模式推断
14563703 RGD
involved in response to odorant IEP
IEP: 通过表达模式推断
23103411 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18465118 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
9876020 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
15761664 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
19284293 RGD
located in microvillus IDA
IDA: 通过直接分析推断
15085256 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
16176344 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
18410501 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ctsl 蛋白结构

Inhibitor_I29

Inhibitor_I29: smart00848 (28 - 86)

Peptidase_C1

Peptidase_C1: pfam00112 (113 - 331)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
蛋白主名 其他名称

procathepsin L

CP-2

MEP

cathepsin L1

cyclic protein 2

major excreted protein

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 99.29% Phase 2
HY-137978 Ezurpimtrostat Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128140 Z-FY-CHO Inhibitor 96.18% 否
HY-119293 K777 99.77% 否
HY-RS03340 CTSL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-119293A K777 tosylate / 否
HY-157477 SARS-CoV-2 3CLpro-IN-22 Inhibitor / 否
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / 否
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / 否
HY-RS03341 Ctsl Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03342 Ctsl Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-163029 CTSL/B-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctsl NCBI NCBI:1514
Mus musculus Ctsl NCBI NCBI:13039
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