1. Metabolic Enzyme/Protease Immunology/Inflammation GPCR/G Protein Anti-infection
  2. Cathepsin CCR Cytochrome P450 Parasite SARS-CoV Filovirus
  3. K777 tosylate

K777 tosylate 是一种有效的,口服活性且不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂,也是一种有效的 CYP3A4 抑制剂,IC50 为 60 nM,是一种选择性的 CCR4 拮抗剂,具有强的趋化性抑制作用。K777 tosylate 不可逆地抑制锥虫(克鲁斯锥虫的主要半胱氨酸蛋白酶)和组织蛋白酶 B 和 L。K777 tosylate 是一种广谱抗病毒活性分子,通过靶向组织蛋白酶介导的细胞进入。K777 tosylate 抑制 SARS-CoVEBOV 病毒的进入,IC50 值分别为 0.68 nM 和 0.87 nM。

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K777 tosylate Chemical Structure

K777 tosylate Chemical Structure

CAS No. : 502960-91-0

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

K777 tosylate is a potent, orally active and irreversible cysteine protease inhibitor. K777 tosylate is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 tosylate irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 tosylate is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 tosylate inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively[1][2][3].

分子量

746.94

Formula

C39H46N4O7S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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K777 tosylate
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HY-119293A
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