CHRDL2 - chordin like 2 Gene

中文名称：chordin 样 2

种属: Homo sapiens

同用名: BNF1; CHL2

关于 CHRDL2

功能概要

该基因编码 chordin 蛋白质家族的成员。 Chordin 家族成员是分泌型蛋白质，它们共享富含半胱氨酸的前胶原重复结构域，并与转化生长因子 β 超家族的成员相关联。体外试验表明编码蛋白与人激活素 A 之间存在直接相互作用。该基因在包括成骨细胞在内的许多组织中表达，在分化过程中差异表达。此外，它在人类骨关节炎关节软骨中的表达上调，表明它在成人软骨再生中发挥作用。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human Activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]