1. Gene
  2. GPSM1 - G protein signaling modulator 1 Gene

GPSM1 - G protein signaling modulator 1 Gene

中文名称:G 蛋白信号调节因子 1

种属: Homo sapiens

同用名: AGS3

基因 ID: 26086 | 基因类型: protein coding

关于 GPSM1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,327,539-136,359,601 (from NCBI)

This gene has 6 transcripts (splice variants), 219 orthologues and 6 paralogues. Broad expression in brain (RPKM 5.1), testis (RPKM 4.7) and 24 other tissues.

功能概要

蛋白信号调节剂 (GPSM) 通过与 G 蛋白亚基的相互作用发挥多种功能作用。该基因编码 G 蛋白信号传导的受体非依赖性激活剂,这是影响 G 蛋白信号传导系统基础活性的几个因素之一。该蛋白质在其 N 端一半包含七个四肽重复序列,在其 C 端一半包含四个 G 蛋白调节 (GPR) 基序。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供,2011 年 12 月]

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GPSM1 基因产物(5)

mRNA Protein Name
NM_001145638.3 NP_001139110.2 G-protein-signaling modulator 1 isoform a
NM_001145639.2 NP_001139111.1 G-protein-signaling modulator 1 isoform c
NM_001200003.2 NP_001186932.1 G-protein-signaling modulator 1 isoform c
NM_001412257.1 NP_001399186.1 G-protein-signaling modulator 1 isoform d
NM_015597.6 NP_056412.5 G-protein-signaling modulator 1 isoform b

GPSM1 蛋白结构

TPR_1

TPR_1: Tetratricopeptide repeat (68 - 89)

TPR_12

TPR_12: Tetratricopeptide repeat (109 - 162)

TPR_7

TPR_7: Tetratricopeptide repeat (211 - 245)

TPR_12

TPR_12: Tetratricopeptide repeat (250 - 316)

GoLoco

GoLoco: GoLoco motif (496 - 517)

GoLoco

GoLoco: GoLoco motif (548 - 569)

GoLoco

GoLoco: GoLoco motif (597 - 617)

GoLoco

GoLoco: GoLoco motif (630 - 652)

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  • 675 a.a.
蛋白主名 其他名称

G-protein-signaling modulator 1

G-protein signalling modulator 1 (AGS3-like, C. elegans)

关联疾病

疾病名称 别名
Peroxisome Biogenesis Disorder 2a

PBD2A

Peroxisome Biogenesis Disorder Complementation Group 2

PBD-CG2

Cg1

Pbd-Cge

Peroxisome Biogenesis Disorder Complementation Group E

Peroxisome Biogenesis Disorder, Type 2a

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus GPSM1 VGNC VGNC:62697
Bos taurus GPSM1 VGNC VGNC:29614
Macaca mulatta GPSM1 VGNC VGNC:72960
Mus musculus GPSM1 MGD MGI:1915089
Rattus norvegicus GPSM1 RGD RGD:628682
Canis familiaris GPSM1 VGNC VGNC:41457