1. Gene
  2. KCNG2 - potassium voltage-gated channel modifier subfamily G member 2 Gene

KCNG2 - potassium voltage-gated channel modifier subfamily G member 2 Gene

中文名称:钾电压门控通道调节因子亚科 G 成员 2

种属: Homo sapiens

同用名: KCNF2; KV6.2

基因 ID: 26251 | 基因类型: protein coding

关于 KCNG2

Cytogenetic location: 18q23 Genomic coordinates (GRCh38): 18:79,797,938-79,900,100 (from NCBI)

This gene has 2 transcripts (splice variants), 184 orthologues and 31 paralogues. Low expression observed in reference dataset.

功能概要

从功能和结构的角度来看,电压门控钾 (Kv) 通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码电压门控钾通道 G 亚科的一个成员。该成员是电压门控钾通道的一个 γ 亚基。包含该亚基的延迟整流型通道可能有助于心脏动作电位复极化。[RefSeq 提供,2008 年 7 月]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated Potassium Channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]

KCNG2 基因产物(1)

mRNA Protein Name
NM_012283.2 NP_036415.1 potassium voltage-gated channel subfamily G member 2

KCNG2 蛋白结构

BTB_2

BTB_2: BTB/POZ domain (19 - 118)

Ion_trans

Ion_trans: Ion transport protein (220 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
蛋白主名 其他名称

potassium voltage-gated channel subfamily G member 2

cardiac potassium channel subunit

关联疾病

疾病名称 别名
Sick Sinus Syndrome

Sinus Node Dysfunction

Sinus Node Disease

Sinus Node Infection

Snd

Sss

Snd - [Sinus Node Dysfunction]

Sinoatrial Node Dysfunction

Sss - [Sick Sinus Syndrome]

Sick Sinus

Sick Sinus Tachycardia

Pyromania

Firesetting Behavior

Pathological Firesetting

Pathological Fire-Setting

Opioid Abuse

Opioid-Related Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus KCNG2 VGNC VGNC:30443
Mus musculus KCNG2 MGD MGI:3694646
Macaca mulatta KCNG2 VGNC VGNC:104227
Felis catus KCNG2 VGNC VGNC:107711
Rattus norvegicus KCNG2 RGD RGD:1309521
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