Mapk3 - mitogen-activated protein kinase 3 Gene

中文名称：丝裂原活化蛋白激酶3

种属: Mus musculus

同用名: p44; Erk1; Ert2; Mnk1; Erk-1; Esrk1; Prkm3; Mtap2k; p44erk1; p44mapk

关于 Mapk3

功能概要

该基因编码的蛋白可启动 MAP 激酶活性； MAP激酶激酶活性；和磷酸酪氨酸残基结合活性。参与多个过程，包括载脂蛋白结合活性的负调节； DNA 结合转录因子活性的调节；和疼痛的感官知觉。作用于多个过程的上游或内部，包括 Bergmann 神经胶质细胞分化； ERK1 和 ERK2 级联；和动物器官发育。位于胞质溶胶中；核;和伪讲台。以多种结构表达，包括消化系统；早孕;泌尿生殖系统；神经系统;和感觉器官。该基因的人类直系同源物与结肠腺癌有关；结直肠腺癌；子宫内膜腺癌；胰腺导管癌；和肺动脉高压。与人 MAPK3（丝裂原活化蛋白激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of Apolipoprotein binding activity; regulation of DNA-binding transcription factor activity; and sensory perception of pain. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and animal organ development. Located in cytosol; nucleus; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]