2. Gene
  3. DHDH - dihydrodiol dehydrogenase Gene

DHDH - dihydrodiol dehydrogenase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二氢二醇脱氢酶

种属: Homo sapiens

同用名: 2DD; HUM2DD

基因 ID: 27294 | 基因类型: protein coding

关于 DHDH

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,932,795-48,944,969 (from NCBI)

This gene has 4 transcripts (splice variants), 287 orthologues and 3 paralogues. Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues.

功能概要

该基因编码一种属于二氢二醇脱氢酶家族的酶，该酶以多种形式存在于哺乳动物组织中，并参与外源物质和糖类的代谢。这些酶催化 NADP1 连接的芳烃反式二氢二醇氧化成相应的儿茶酚。该酶是一种二聚二氢二醇脱氢酶，它与单体二氢二醇脱氢酶的不同之处在于它在氧化方向上对芳烃的反式二氢二醇具有高底物特异性。[RefSeq 提供，2008 年 7 月]

This gene encodes an Enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These Enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This Enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]

DHDH 基因产物(1)

mRNA Protein Name
NM_014475.4 NP_055290.1 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

DHDH 蛋白结构

GFO_IDH_MocA

GFO_IDH_MocA: Oxidoreductase family, NAD-binding Rossmann fold (3 - 117)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
蛋白主名 其他名称

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

3-deoxyglucosone reductase

关联疾病

疾病名称 别名
Congenital Myasthenic Syndrome 7

Cms7

Congenital Myasthenic Syndrome 7 Presynaptic

Myasthenic Syndrome, Congenital, Type 7, Presynaptic
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03729 DHDH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DHDH VGNC VGNC:39929
Rattus norvegicus DHDH RGD RGD:1588686
Mus musculus DHDH MGD MGI:1919005
Bos taurus DHDH VGNC VGNC:28036
Macaca mulatta DHDH VGNC VGNC:71653
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