Tlr1 - toll-like receptor 1 Gene

中文名称：Toll样受体 1

种属: Rattus norvegicus

关于 Tlr1

功能概要

该基因编码的蛋白可启动脂肽结合活性。参与小胶质细胞活化；对细菌脂蛋白的反应；和 toll 样受体信号通路。预测位于高尔基体和膜筏。预计是 Toll 样受体 1-Toll 样受体 2 蛋白复合物的一部分。围产期坏死性小肠结肠炎的生物标志物。该基因的人类直系同源基因与多种疾病有关，包括 IgA 肾小球肾炎；曲霉病;麻风;肾盂肾炎;和肺结核。与人类 TLR1（toll 样受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Lipopeptide binding activity. Involved in microglial cell activation; response to Bacterial lipoprotein; and Toll-like Receptor signaling pathway. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]