1. Gene
  2. TLR1 - toll like receptor 1 Gene

TLR1 - toll like receptor 1 Gene

中文名称:toll 样受体 1

种属: Homo sapiens

同用名: TIL; CD281; rsc786; TIL. LPRS5

基因 ID: 7096 | 基因类型: protein coding

关于 TLR1

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,787,569-38,805,644 (from NCBI)

This gene has 10 transcripts (splice variants), 73 orthologues, 22 paralogues and is associated with 1 phenotype. Broad expression in appendix (RPKM 7.0), spleen (RPKM 4.9) and 24 other tissues.

功能概要

该基因编码的蛋白质是 Toll 样受体 (TLR) 家族的成员,该家族在病原体识别和先天免疫激活中起着重要作用。 TLR 从果蝇到人类高度保守,并具有结构和功能相似性。它们识别在传染原上表达的病原体相关分子模式 (PAMP) ,并介导产生有效免疫力所必需的细胞因子。各种 TLR 表现出不同的表达模式。该基因普遍表达,表达水平高于其他 TLR 基因。不同长度的转录本可能是由于使用替代聚腺苷酸化位点和/或替代剪接引起的,已经注意到该基因。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than Other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]

TLR1 基因产物(11)

mRNA Protein Name
XM_011513742.4 XP_011512044.1 toll-like receptor 1 isoform X1
XR_007057954.1
XM_011513745.4 XP_011512047.1 toll-like receptor 1 isoform X1
XM_005262662.6 XP_005262719.1 toll-like receptor 1 isoform X1
XR_007057953.1
XM_017008571.3 XP_016864060.1 toll-like receptor 1 isoform X1
XR_925165.3
NM_003263.4 NP_003254.2 toll-like receptor 1 precursor
XM_024454196.2 XP_024309964.1 toll-like receptor 1 isoform X1
XM_017008572.3 XP_016864061.1 toll-like receptor 1 isoform X1
XR_925163.3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Toll-like receptor 2 binding IPI
IPI: 通过物理相互作用推断
16880211 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23155421 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15728506 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
16880211 GOA
part of Toll-like receptor 1-Toll-like receptor 2 protein complex IDA
IDA: 通过直接分析推断
17889651 GOA
part of Toll-like receptor 1-Toll-like receptor 2 protein complex IPI
IPI: 通过物理相互作用推断
17889651 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
16880211 GOA
part of receptor complex IPI
IPI: 通过物理相互作用推断
23155421 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TLR1 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (69 - 125)

LRR_8

LRR_8: Leucine rich repeat (445 - 500)

TIR

TIR: TIR domain (639 - 774)

  • 0
  • 200
  • 400
  • 600
  • 786 a.a.
蛋白主名 其他名称

toll-like receptor 1

toll/interleukin-1 receptor-like protein

TLR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TLR1 Q15399 TLR6 Homo sapiens Q9Y2C9
ToxCat
23155421
种属内
TLR1 Q15399 TLR6 Homo sapiens Q9Y2C9
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 TLR10 Homo sapiens Q9BXR5
ToxCat
23155421
种属内
TLR1 Q15399 TLR10 Homo sapiens Q9BXR5
Anti Tag CoIP
15728506
种属内
TLR1 Q15399 TLR2 Homo sapiens O60603
FRET
23155421
种属内
TLR1 Q15399 TMEM214 Homo sapiens Q6NUQ4
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 TLR2 Homo sapiens O60603
ToxCat
23155421
种属内
TLR1 Q15399 TLR1 Homo sapiens Q15399
Fluorescence
23155421
种属内
TLR1 Q15399 TLR1 Homo sapiens Q15399
ToxCat
23155421
种属内
TLR1 Q15399 COLEC12 Homo sapiens Q5KU26
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 DERA Homo sapiens Q9Y315
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 TMX1 Homo sapiens Q9H3N1
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 LRP6 Homo sapiens O75581
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 MUCL1 Homo sapiens Q96DR8
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 STK11IP Homo sapiens Q8N1F8
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 CNPY3 Homo sapiens Q9BT09
Anti Tag CoIP
33961781
种属内
TLR1 Q15399 ALDH16A1 Homo sapiens Q8IZ83
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Filariasis

Disease Due To Superfamily Filarioidea

Bancroftian Filarial Fever

Mumu

Wanganga

Bancroftian Filariasis

Wuchereriosis

Brugiosis

Malayan Filariasis

Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease

Bacteriuria
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Primary Bacterial Infectious Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculosis, Susceptibility To

Tuberculoma

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma

Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Lepromatous Leprosy

Leprosy, Lepromatous

Type L Leprosy

Leprosy Lepromatous

Toxoplasmosis

Disseminated Toxoplasmosis

Multisystemic Disseminated Toxoplasmosis

Acquired Toxoplasmosis

Toxoplasmosis Disease Or Disorder

Infection By Toxoplasma Gondii

Toxoplasmal

Toxoplasma

Pharyngitis

Acute Pharyngitis

Chronic Pharyngitis

Acute Sore Throat

Chronic Sore Throat

Persistent Sore Throat

Pharyngeal Diseases

Chronic Pharyn/Nasopharyngitis

Chronic Pharyngitis And Nasopharyngitis

Inflamed Throat

Pharyngeal Disease

Pharyngeal Disorder

Pharyngitis - Acute

Sore Throat - Chronic

Acute Pharyngitis Nos

Acute Sore Throat Nos

Acute Throat Inflammation

Infective Pharyngitis

Infection Of Pharynx

Acute Infective Pharyngitis

Acute Infective Pharyngitis Nos

Acute Pharyngeal Inflammation

Inflammation Of The Throat

Throat Inflammation

Throat Infection

Putrid Pharyngitis

Pharyngeal Inflammation

Pharyngitis Nos

Chronic Throat Pain

Throat Catarrh

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Pelvic Inflammatory Disease

Pid

Lyme Disease

Lyme Borreliosis

Lyme Neuroborreliosis

Borreliosis

Borrelia Burgdorferi Infection

Neuroborreliosis

Bannwarth Syndrome

Bannworth'S Syndrome

Neurological Lyme Disease

B. Burgdorferi Infection

Borreliosis, Lyme

Infection By Borrelia Burgdorferi

Infection Due To Borrelia Burgdorferi Sensu Lato

Lym

Borrelia Infections

Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis

Leptospirosis

Fort Bragg Fever

Weil Disease

Leptospirosis Icterohaemorrhagica

Nanukayami Fever

Canicola Fever

Hemorrhagic Jaundice

Mud Fever

Stuttgart Disease

Swamp Fever

Rat Catcher'S Yellows

Spirochetal Jaundice

Weil'S Disease

Cane-Cutter Fever

Icterohemorrhagic Fever

Rice-Field Fever

Swineherd'S Disease

Weil Syndrome

Nanukayami

Canine Leptospirosis

Equine Infectious Anemia

Leptospirosis Canicola

Fever Due To Leptospira Autumnalis

Gikiyami

Leptospira Interrogans Autumnalis Infection

Leptospira Interrogans Canicola Infection

Leptospira Interrogans Hebdomadis Infection

Leptospira Interrogans Pomona Infection

Nanukayami Disease

Pretibial Fever

Seven-Day Fever

Eia - [Equine Infectious Anaemia]

Leptospira Interrogans Infection

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Viral Infectious Disease

Arbovirus Infections

Viral Disease

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Leprosy 5

Leprosy, Susceptibility To, 5

Leprosy, Protection Against

LPRS5

Leprosy, Type 5

Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Q Fever

Infection Due To Coxiella Burnetii

Quadrilateral Fever

Query Fever

Nine Mile Fever

Coxiella Burnetii Fever

Q Fever Pneumonia

Coxiellosis

Pneumonia In Q Fever

Australian Q Fever

Balkan Grippe

Tuberculoid Leprosy

Smooth Leprosy

Type T Leprosy

Leprosy Tuberculoid

Leprosy, Tuberculoid

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Neurosyphilis

Syphilis Of Central Nervous System

Late Syphilis Of Central Nervous System Nos

Late Syphilis Of The Central Nervous System

Gumma Of Central Nervous System

Neurosyphilis Gumma

Neurosyphilitic Gumma

Syphilis Of Central Nervous System Nos

Syphilitic Gumma Of Central Nervous System

Tertiary Central Nervous System Syphilis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TLR1 VGNC VGNC:78372
Canis familiaris TLR1 VGNC VGNC:53247
Rattus norvegicus TLR1 RGD RGD:1309975
Mus musculus TLR1 MGD MGI:1341295
Felis catus TLR1 VGNC VGNC:82315