2. Gene
  3. TLR10 - toll like receptor 10 Gene

TLR10 - toll like receptor 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：toll 样受体 10

种属: Homo sapiens

同用名: CD290

基因 ID: 81793 | 基因类型: protein coding

关于 TLR10

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:38,772,238-38,782,990 (from NCBI)

This gene has 8 transcripts (splice variants), 56 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 20.4), spleen (RPKM 11.7) and 3 other tissues.

功能概要

该基因编码的蛋白质是 Toll 样受体 (TLR) 家族的成员，该家族在病原体识别和先天免疫激活中起着重要作用。 TLR 从果蝇到人类高度保守，并具有结构和功能相似性。它们识别在传染原上表达的病原体相关分子模式 (PAMP) ，并介导产生有效免疫力所必需的细胞因子。各种 TLR 表现出不同的表达模式。该基因在淋巴组织如脾脏、淋巴结、胸腺和扁桃体中表达最高。已针对该基因发现了编码不同蛋白质亚型的多个选择性剪接转录物变体。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

TLR10 基因产物(5)

mRNA Protein Name
NM_001017388.3 NP_001017388.1 toll-like receptor 10 isoform a
NM_001195106.2 NP_001182035.1 toll-like receptor 10 isoform a
NM_001195107.2 NP_001182036.1 toll-like receptor 10 isoform a
NM_001195108.2 NP_001182037.1 toll-like receptor 10 isoform b
NM_030956.4 NP_112218.2 toll-like receptor 10 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15728506 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15728506 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IPI
IPI: 通过物理相互作用推断
23155421 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TLR10 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (72 - 128)

(372 - 387)

LRR_1

LRR_1: Leucine Rich Repeat (444 - 461)

TIR

TIR: TIR domain (636 - 773)

  • 0
  • 200
  • 400
  • 600
  • 811 a.a.
蛋白主名 其他名称

toll-like receptor 10

关联疾病

疾病名称 别名
Melioidosis

Melioidosis, Susceptibility To

Acute And Fulminating Melioidosis

Nightcliff Gardener'S Disease

Pseudoglanders

Subacute And Chronic Melioidosis

Burkholderia Pseudomallei Infection

Whitmore Disease

Whitmore'S Disease

B Pseudomallei Infection

Epizootic Lymphangitis

Infection Due To Burkholderia Pseudomallei

Infection Due To Burkholderia Pseudomallei Nos

Infection Due To Malleomyces Pseudomallei

Infection Due To Pseudomonas Pseudomallei

Infection Due To Pseudomonas Pseudomallei Nos

Infection Due To Whitmore Bacillus

Stanton Disease
Q Fever

Infection Due To Coxiella Burnetii

Quadrilateral Fever

Query Fever

Nine Mile Fever

Coxiella Burnetii Fever

Q Fever Pneumonia

Coxiellosis

Pneumonia In Q Fever

Australian Q Fever

Balkan Grippe
Tonsillitis

Chronic Tonsillitis

Throat Infection - Tonsillitis
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14579 TLR10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TLR10 VGNC VGNC:66217
Canis familiaris TLR10 VGNC VGNC:53248
Macaca mulatta TLR10 VGNC VGNC:78392
Rattus norvegicus TLR10 RGD RGD:1311569
Bos taurus TLR10 VGNC VGNC:50019
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