2. Gene
  3. HCAR2 - hydroxycarboxylic acid receptor 2 Gene

HCAR2 - hydroxycarboxylic acid receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羟基羧酸受体 2

种属: Homo sapiens

同用名: HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A

基因 ID: 338442 | 基因类型: protein coding

关于 HCAR2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,701,293-122,703,357 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 15 paralogues.

功能概要

预测可启用烟酸受体活性。参与中性粒细胞凋亡过程并正向调节中性粒细胞凋亡过程。位于细胞连接处和质膜上。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable nicotinic acid receptor activity. Involved in neutrophil apoptotic process and positive regulation of neutrophil apoptotic process. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

HCAR2 基因产物(1)

mRNA Protein Name
NM_177551.4 NP_808219.1 hydroxycarboxylic acid receptor 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neutrophil apoptotic process IDA
IDA: 通过直接分析推断
17932499 GOA
involved in positive regulation of neutrophil apoptotic process IDA
IDA: 通过直接分析推断
17932499 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
17932499 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HCAR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 294)

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  • 363 a.a.
蛋白主名 其他名称

hydroxycarboxylic acid receptor 2

G protein-coupled receptor HM74a

G-protein coupled receptor 109A

G-protein coupled receptor HM74A

hydroxy-carboxylic acid receptor 2

niacin receptor 1

nicotinic acid receptor

关联疾病

疾病名称 别名
Pellagra

Niacin Deficiency

Niacin-Tryptophan Deficiency

Pellagroid Syndrome
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Diversion Colitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06038 HCAR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-156025 HCAR2 agonist 1 / 否
HY-RS06039 Hcar2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06040 Hcar2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HCAR2 RGD RGD:727952
Mus musculus HCAR2 MGD MGI:1933383
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