1. Gene
  2. IL12B - interleukin 12B Gene

IL12B - interleukin 12B Gene

中文名称:白细胞介素 12B

种属: Homo sapiens

同用名: CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B

基因 ID: 3593 | 基因类型: protein coding

关于 IL12B

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:159,314,780-159,330,487 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and is associated with 3 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码白细胞介素 12 的一个亚基,白细胞介素 12 是一种作用于 T 细胞和自然杀伤细胞的细胞因子,具有广泛的生物活性。白细胞介素 12 是一种二硫键连接的异二聚体,由该基因编码的 40 kD 细胞因子受体样亚基和 IL12A 编码的 35 kD 亚基组成。这种细胞因子由活化的巨噬细胞表达,作为 Th1 细胞发育的重要诱导剂。已发现这种细胞因子对于维持足够数量的记忆/效应 Th1 细胞以介导对细胞内病原体的长期保护很重要。在多发性硬化症 (MS) 患者的中枢神经系统中观察到该基因的过度表达,表明该细胞因子在该疾病的发病机制中发挥作用。据报道,该基因的启动子多态性与儿童特应性和非特应性哮喘的严重程度有关。[RefSeq 提供,2008 年 7 月]

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

IL12B 基因产物(1)

mRNA Protein Name
NM_002187.3 NP_002178.2 interleukin-12 subunit beta precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to cytokine activity IDA
IDA: 通过直接分析推断
1674604 GOA
enables cytokine activity IDA
IDA: 通过直接分析推断
7584494 GOA
contributes to growth factor activity IDA
IDA: 通过直接分析推断
1674604 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
7527811 GOA
enables interleukin-12 alpha subunit binding IPI
IPI: 通过物理相互作用推断
11023671 GOA
contributes to interleukin-23 receptor binding IDA
IDA: 通过直接分析推断
11114383 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7527811 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
1674604 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper cell differentiation IDA
IDA: 通过直接分析推断
1673147 GOA
involved in cell migration IDA
IDA: 通过直接分析推断
7903063 GOA
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
12023369 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
15114670 GOA
involved in interleukin-12-mediated signaling pathway IDA
IDA: 通过直接分析推断
7584494 GOA
involved in natural killer cell activation IDA
IDA: 通过直接分析推断
1673147 GOA
acts upstream of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IGI
IGI: 通过遗传相互作用推断
30106099 GOA
involved in negative regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
16751425 GOA
involved in negative regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
16482511 GOA
acts upstream of or within negative regulation of protein secretion IGI
IGI: 通过遗传相互作用推断
30106099 GOA
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
16942485 GOA
acts upstream of negative regulation of vascular endothelial growth factor signaling pathway IGI
IGI: 通过遗传相互作用推断
30106099 GOA
involved in positive regulation of NK T cell activation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of NK T cell proliferation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12023369 GOA
involved in positive regulation of T-helper 1 type immune response IDA
IDA: 通过直接分析推断
15114670 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
1674604 GOA
involved in positive regulation of cell adhesion IDA
IDA: 通过直接分析推断
7903063 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
12421946 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: 通过直接分析推断
20027291 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
15265908 GOA
involved in positive regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
20027291 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
16482511 GOA
involved in positive regulation of lymphocyte proliferation IDA
IDA: 通过直接分析推断
1674604 GOA
involved in positive regulation of mononuclear cell proliferation IMP
IMP: 通过突变表型推断
11023671 GOA
involved in positive regulation of natural killer cell activation IDA
IDA: 通过直接分析推断
1674604 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
IDA: 通过直接分析推断
7903063 GOA
involved in positive regulation of natural killer cell proliferation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
17888176 GOA
involved in positive regulation of smooth muscle cell apoptotic process IDA
IDA: 通过直接分析推断
16942485 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16751425 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
1674604 GOA
involved in response to UV-B IDA
IDA: 通过直接分析推断
8992506 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
7584494 GOA
part of interleukin-12 complex IDA
IDA: 通过直接分析推断
1674604 GOA
part of interleukin-23 complex IDA
IDA: 通过直接分析推断
11114383 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IL12B 蛋白结构

IL12p40_C

IL12p40_C: Cytokine interleukin-12p40 C-terminus (125 - 217)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
蛋白主名 其他名称

interleukin-12 subunit beta

CLMF p40

IL-12 subunit p40

IL12, subunit p40

NK cell stimulatory factor chain 2

cytotoxic lymphocyte maturation factor 40 kDa subunit

interleukin 12, p40

interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

interleukin-12 beta chain

natural killer cell stimulatory factor, 40 kD subunit

重组 IL12B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7032 IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P70617 IL-12 beta Protein, Human (HEK293) P29460 (I23-S328) ≥95%
HY-P70736 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, C-His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P7032G GMP IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73160 IL-12 beta Protein, Human (HEK293, Fc) P29460/NP_002178.2 (I23-S328) ≥95%
HY-P73193 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P73898 IL-12 Protein, Human (HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P74816 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P77702 IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P77704 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P700100AF Animal-Free IL-12 beta Protein, Human (His) P29460 (I23-S328) ≥95%

关联疾病

疾病名称 别名
Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To

Psoriasis
Psoriasis 11

PSORS11

Psoriasis 11, Susceptibility To

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Pv

Immunodeficiency 29

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12b Deficiency

IMD29

Il12b Deficiency

Immunodeficiency 29, Mycobacteriosis

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interleukin 12b Deficiency

Msmd Due To Complete Il12b Deficiency

Msmd Due To Complete Interleukin 12b Deficiency

Immunodeficiency, Type 29, Mycobacteriosis

Typhoid Fever

Typhoid

Enteric Fever

Typhoidal Salmonellosis

Ileotyphus

Infection By Salmonella Typhi

Typhoid Any Site

Typhoid Fever Any Site

Typhoid Infection

Typhoid Infection Any Site

Typhoid Fever Confirmed

Enteric Fever Nos

Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Lymphadenitis

Acute Lymphadenitis

Chronic Lymphadenitis

Chronic Adenitis

Acute Adenitis

Adenitis

Inflammation Of Lymph Node

Adenitis Nos

Inflammation Of Gland

Lymphatic Gland Inflammation

Lymph Gland Inflammation

Polyadenitis

Chronic Adenitis Of Any Lymph Node Except Mesenteric

Chronic Lymphadenitis Except Mesenteric

Chronic Non-Specific Lymphadenitis

Paratyphoid Fever

Paratyphoid B Fever

Paratyphoid C Fever

Paratyphoid Fever A

Paratyphoid Fever B

Paratyphoid Fever C

Paratyphoid

Paratyphoid A

Paratyphoid A Fever

Paratyphoid B

Paratyphoid C

Infection Due To Salmonella Paratyphi

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Cysticercosis

Neurocysticercosis

Submacular Cysticercosis

Intestinal Taenia Solium Infection

Pork Tapeworm Infection

Tapeworm Infection: Intestinal Taenia Solum

Tapeworm Infection: Pork

Tenia Solium Infectious Disease

Taeniasis

Tenia Solium Infection

Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Inflammatory Bowel Disease 3

IBD3

Pulmonary Tuberculosis

Tuberculosis, Pulmonary

PTB

Tuberculosis Pulmonary

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Inflammatory Bowel Disease 9

IBD9

Graves' Disease

Graves Disease

Exophthalmic Goiter

Basedow'S Disease

Grave'S Disease

Basedow Disease

Toxic Diffuse Goiter

Graves' Hyperthyroidism

Parry Disease

Autoimmune Hyperthyroidism

Toxic Multinodular Goiter

Takayasu Arteritis

Aortic Arch Syndrome

Pulseless Disease

Idiopathic Aortitis

Young Female Arteritis

Takayasu'S Arteritis

Aortic Arch Arteritis

Aortic Arches Defect

Aortic Arch Defects

Takayasu Disease

Aortic Arch Syndromes

Takayasu'S Disease

Ta

Obliterative Aortitis

Aortic Arch Giant-Cell Arteritis

Subclavian-Carotid Obstruction Syndrome

Idiopathic Medial Aortopathy And Arteriopathy

Takayasu Syndrome

Obliterative Brachiocephalic Arteritis Syndrome

Raeder-Harbitz Syndrome

Chronic Subclavian-Carotid Obstruction Syndrome

Giant-Cell Aortitis

Takayasu Aortitis

Nonspecific Aortoarteritis

Sclerosing Aortitis And Arteritis

Martorell 2 Syndrome

Young Female Aortic Arch Arteritis Syndrome

Hashimoto Thyroiditis

Autoimmune Thyroiditis

Hashimoto Struma

Hashimoto'S Thyroiditis

Chronic Lymphocytic Thyroiditis

Lymphocytic Thyroiditis

Hashimoto Disease

Ht

Hashimoto'S Disease

Hashimoto'S Syndrome

Hypothyroidism, Autoimmune

Autoimmune Chronic Lymphocytic Thyroiditis

Chronic Lymphocytic Thyroiditides

Hashimoto Syndrome

Hashimotos Thyroiditis

Hashimoto Thyroiditis, Susceptibility To

Thyroiditis, Autoimmune

Lymphomatous Thyroiditis

Lymphoid Thyroiditis

Chronic Lymphadenoid Thyroiditis

Autoimmune Lymphocytic Chronic Thyroiditis

Goitre Lymphomatosa

Hashitoxicosis

Hashimoto Hypothyroidism

Lymphadenoid Goitre

Struma Lymphomatosa

Hyperthyroidism With Hashimoto Disease

Hashimoto Thyrotoxicosis

Thyrotoxicosis Due To Hashimoto Thyroiditis

Struma Lymphomatosis

Lymphadenoid Struma

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculosis, Susceptibility To

Tuberculoma

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IL12B VGNC VGNC:73706
Felis catus IL12B VGNC VGNC:67756
Canis familiaris IL12B VGNC VGNC:41933
Rattus norvegicus IL12B RGD RGD:628704
Mus musculus IL12B MGD MGI:96540
Bos taurus IL12B VGNC VGNC:30111
Others IL12B NCBI