IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer 蛋白, Human (Biotinylated, HEK293, His)

IL-23, collaborating with IL12B, constitutes the pro-inflammatory cytokine IL-23, crucial in innate and adaptive immunity. Released by antigen-presenting cells like dendritic cells or macrophages, IL-23 binds to IL12RB1 and IL23R, activating JAK2 and TYK2. This cascade phosphorylates STAT3 and STAT4, activating pathways like p38 MAPK or NF-kappa-B, inducing pro-inflammatory cytokines. IL-23 contributes to intracellular bacterial clearance and supports the expansion of T-helper 17 cells, including IL-17 producers. The disulfide-linked IL-23 interacts with IL12B and IL23R, recruiting IL12RB1. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha, expressed by HEK293, with C-His labeled tag. IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His), has molecular weight of ~55.8 kDa.

IL-23 与 IL12B 协同形成促炎细胞因子 IL-23，在先天免疫和适应性免疫中发挥多种作用。IL-23 由树突状细胞或巨噬细胞等抗原呈递细胞释放，与包含 IL12RB1 和 IL23R 的异二聚体受体复合物结合，启动涉及 JAK2 和 TYK2 激活的级联反应。这些激酶磷酸化受体，为随后的 STAT3 和 STAT4 磷酸化创建对接位点。该过程激活多种途径，包括 p38 MAPK 或 NF-kappa-B，促进促炎细胞因子的产生，例如 IL-17A/IL17A。此外，IL-23 积极参与细胞内细菌的早期有效清除。值得注意的是，IL-23 促进 T 辅助细胞 17 细胞的扩增和存活，T 辅助细胞 17 是一种以产生 IL-17 的 CD4 阳性辅助 T 细胞亚群，以及其他产生 IL-17 的细胞。IL-23 与 IL12B 的异二聚体（称为白细胞介素 IL-23）是二硫键连接的。此外，IL-23 与 IL23R 相互作用，促进 IL12RB1 的募集。

Human

HEK293

C-His

Q9NPF7 (R20-P189)&P29460 (I23-S328)

51561  [NCBI]&3593  [NCBI]

Approximately 55.8 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.