IL23A - interleukin 23 subunit alpha Gene

中文名称：白细胞介素 23 亚基α

种属: Homo sapiens

同用名: P19; SGRF; IL-23; IL-23A; IL23P19

基因 ID: 51561 | 基因类型: protein coding

关于 IL23A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,338,884-56,340,410 (from NCBI)

This gene has 3 transcripts (splice variants) and 96 orthologues. Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues.

功能概要

该基因编码异二聚体细胞因子白细胞介素 23 (IL23) 的一个亚基。 IL23 由这种蛋白质和白细胞介素 12 (IL12B) 的 p40 亚基组成。 IL23 的受体由 IL12 的 β1 亚基 (IL12RB1) 和 IL23 特异性亚基 IL23R 形成。 IL23 和 IL12 均可激活转录激活因子 STAT4，并刺激干扰素-γ (IFNG) 的产生。与主要作用于幼稚 CD4 (+) T 细胞的 IL12 相比，IL23 优先作用于记忆性 CD4 (+) T 细胞。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

IL23A 基因产物(1)

mRNA	Protein	Name
NM_016584.3	NP_057668.1	interleukin-23 subunit alpha precursor

IL23A 蛋白结构

IL6

0
100
189 a.a.

蛋白主名

其他名称

interleukin-23 subunit alpha

IL-23 subunit alpha	IL-23-A
IL-23p19	JKA3 induced upon T-cell activation
interleukin 23 p19 subunit	interleukin 23, alpha subunit p19
interleukin-23 subunit p19	interleukin-six, G-CSF related factor

重组 IL23A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70736	IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, C-His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥95%
HY-P73193	IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥95%
HY-P74816	IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥95%
HY-P74874	Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His)	Q9NPF7 (R20-P189)&P43432 (M23-S335)	≥95%
HY-P76432	IL-23 alpha Protein, Human (HEK293, Fc)	Q9NPF7 (R20-P189)	≥95%
HY-P77704	IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi)	Q9NPF7 (R20-P189)&P29460 (I23-S328)	≥95%
HY-P77712	Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi)	Q9NPF7 (R20-P189)&P43432 (M23-S335)	≥95%
HY-P700114AF	Animal-Free IL-23 p19 Protein, Human (His)	Q9NPF7 (R20-P189)	≥95%

关联疾病

疾病名称

别名

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Psoriasis

Hidradenitis

Hydradenitis

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Autoimmune Disease Of Skin And Connective Tissue

Autoimmune Cholangitis

Autoimmune Cholangiopathy

Aspergillosis

Aspergillosis, Susceptibility To	Infection Due To Aspergillus
Aspergilloma	Aspergillus Nodule
Simple Aspergilloma	Aspergillus
Aspergillus Flavus Infection	Aspergillus Fumigatus Infection
Aspergillus Infection	Infection By Aspergillus Fumigatus
Intracavitary Aspergillus Fungus Ball	Aspergillus Terreus

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Enteritis, Granulomatous	Crohn'S Disease Of Colon
Granulomatous Colitis	Colitis, Granulomatous
Crohn'S Enteritis	Enteritis, Regional
Enteritis	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Colitis

Erythema Nodosum

Hidradenitis Suppurativa

Acne Inversa	Suppurative Hidradenitis
Acne Inversa, Familial	Apocrinitis
Hidradenitides, Suppurative	Hidradenitis, Suppurative
Suppurative Hidradenitides	Inverse Acne

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Spondyloarthropathy

Spondylarthropathies	Spondarthropathy
Spondylarthrosis	Spondyloarthropathy, Susceptibility To
Spondylarthritis

Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Spondylitis

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06739	IL23A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06740	Il23a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06741	Il23a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990057	Picankibart	Inhibitor	98.00%	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL23A	MGD	MGI:1932410
Bos taurus	IL23A	VGNC	VGNC:30146
Canis familiaris	IL23A	VGNC	VGNC:41972
Felis catus	IL23A	VGNC	VGNC:62907
Macaca mulatta	IL23A	VGNC	VGNC:73601
Rattus norvegicus	IL23A	RGD	RGD:620873
Others	IL23A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL23A - interleukin 23 subunit alpha Gene

关于 IL23A

功能概要

IL23A 基因产物(1)

IL23A 蛋白结构

重组 IL23A 蛋白

关联疾病

直系同源

热门区域

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IL23A - interleukin 23 subunit alpha Gene

关于 IL23A

功能概要

IL23A 基因产物(1)

IL23A 蛋白结构

重组 IL23A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z