2. Gene
  3. IL23A - interleukin 23 subunit alpha Gene

IL23A - interleukin 23 subunit alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 23 亚基α

种属: Homo sapiens

同用名: P19; SGRF; IL-23; IL-23A; IL23P19

基因 ID: 51561 | 基因类型: protein coding

关于 IL23A

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,338,884-56,340,410 (from NCBI)

This gene has 3 transcripts (splice variants) and 96 orthologues. Biased expression in testis (RPKM 4.7), urinary bladder (RPKM 2.4) and 11 other tissues.

功能概要

该基因编码异二聚体细胞因子白细胞介素 23 (IL23) 的一个亚基。 IL23 由这种蛋白质和白细胞介素 12 (IL12B) 的 p40 亚基组成。 IL23 的受体由 IL12 的 β1 亚基 (IL12RB1) 和 IL23 特异性亚基 IL23R 形成。 IL23 和 IL12 均可激活转录激活因子 STAT4，并刺激干扰素-γ (IFNG) 的产生。与主要作用于幼稚 CD4 (+) T 细胞的 IL12 相比，IL23 优先作用于记忆性 CD4 (+) T 细胞。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

IL23A 基因产物(1)

mRNA Protein Name
NM_016584.3 NP_057668.1 interleukin-23 subunit alpha precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to interleukin-23 receptor binding IDA
IDA: 通过直接分析推断
11114383 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11114383 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
12023369 GOA
involved in cell surface receptor signaling pathway via STAT IDA
IDA: 通过直接分析推断
19088061 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: 通过直接分析推断
15114670 GOA
involved in negative regulation of interleukin-10 production IMP
IMP: 通过突变表型推断
16751425 GOA
involved in positive regulation of NK T cell activation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of NK T cell proliferation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12023369 GOA
involved in positive regulation of T-helper 1 type immune response IDA
IDA: 通过直接分析推断
15114670 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
11114383 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
12421946 GOA
involved in positive regulation of granulocyte macrophage colony-stimulating factor production IDA
IDA: 通过直接分析推断
20027291 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
15265908 GOA
involved in positive regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
20027291 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
16482511 GOA
involved in positive regulation of natural killer cell proliferation IDA
IDA: 通过直接分析推断
19088061 GOA
involved in positive regulation of osteoclast differentiation IDA
IDA: 通过直接分析推断
17888176 GOA
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
16751425 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
11114383 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of interleukin-23 complex IDA
IDA: 通过直接分析推断
11114383 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL23A 蛋白结构

IL6

IL6: Interleukin-6/G-CSF/MGF family (66 - 179)

  • 0
  • 100
  • 189 a.a.
蛋白主名 其他名称

interleukin-23 subunit alpha

IL-23 subunit alpha

IL-23-A

IL-23p19

JKA3 induced upon T-cell activation

interleukin 23 p19 subunit

interleukin 23, alpha subunit p19

interleukin-23 subunit p19

interleukin-six, G-CSF related factor

IL23A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL23A Q9NPF7 IL23R Homo sapiens Q5VWK5
Anti Tag CoIP
12023369
种属内
IL23A Q9NPF7 IL12B Homo sapiens P29460
X-Ray Diffraction
18680750
种属内
IL23A Q9NPF7 IL12B Homo sapiens P29460
Anti Tag CoIP
12023369
种属内
IL23A Q9NPF7 IL12B Homo sapiens P29460
Anti Tag CoIP
11114383
种属内
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Validated Y2H
25416956
种属内
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Y2H Prey Pooling
32296183
种属内
IL23A Q9NPF7 PEX19 Homo sapiens P40855
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL23A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70736 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, C-His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P73193 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P74816 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (Biotinylated, HEK293, His) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P74874 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P76432 IL-23 alpha Protein, Human (HEK293, Fc) Q9NPF7 (R20-P189) ≥95%
HY-P77704 IL-23 alpha (170a.a) & IL-12 beta (306a.a) Heterodimer Protein, Human (HEK293, His-Avi) Q9NPF7 (R20-P189)&P29460 (I23-S328) ≥95%
HY-P77712 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P700114AF Animal-Free IL-23 alpha Protein, Human (His) Q9NPF7 (R20-P189) ≥95%

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Candidiasis

Systemic Candidiasis

Invasive Candidiasis

Disseminated Candidiasis

Systemic Candida Infections

Candidiasis, Invasive
Psoriasis
Hidradenitis

Hydradenitis
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To
Autoimmune Disease Of Skin And Connective Tissue
Autoimmune Cholangitis

Autoimmune Cholangiopathy
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Enteritis, Granulomatous

Crohn'S Disease Of Colon

Granulomatous Colitis

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Enteritis

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Colitis
Erythema Nodosum
Hidradenitis Suppurativa

Acne Inversa

Suppurative Hidradenitis

Acne Inversa, Familial

Apocrinitis

Hidradenitides, Suppurative

Hidradenitis, Suppurative

Suppurative Hidradenitides

Inverse Acne
Disease By Infectious Agent

Infectious Disease

Infectious Diseases
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Spondyloarthropathy

Spondylarthropathies

Spondarthropathy

Spondylarthrosis

Spondyloarthropathy, Susceptibility To

Spondylarthritis
Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder
Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly
Spondylitis
Gastroenteritis

Cholera Morbus

Infectious Colitis, Enteritis And Gastroenteritis

Enteritis Due To Astrovirus

Rotaviral Gastroenteritis

Viral Gastroenteritis Due To Rotavirus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06739 IL23A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06740 Il23a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06741 Il23a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990057 Picankibart Inhibitor 98.00% 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IL23A MGD MGI:1932410
Bos taurus IL23A VGNC VGNC:30146
Canis familiaris IL23A VGNC VGNC:41972
Felis catus IL23A VGNC VGNC:62907
Macaca mulatta IL23A VGNC VGNC:73601
Rattus norvegicus IL23A RGD RGD:620873
Others IL23A NCBI
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