2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. BuChE-IN-6

BuChE-IN-6 (compound 1b) 是一种有效的选择性的 BuChEIC50 分别为 0.46 和 0.51 μM。BuChE-IN-6 也抑制 Aβ42 自聚集。

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BuChE-IN-6 Chemical Structure

BuChE-IN-6 Chemical Structure

CAS No. : 2003213-07-6

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BuChE-IN-6 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BuChE-IN-6 (compound 1b) is a potent and selective BuChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.46 and 0.51 μM for eqBuChE and hBuChE, respectively. BuChE-IN-6 also inhibits Aβ42 self-aggregation[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
53.8 μM
Compound: 1b
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
HEK293 IC50
23.1 μM
Compound: 1b
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
MCF-10A IC50
1.08 μM
Compound: 1b
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
MCF7 IC50
1.34 μM
Compound: 1b
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
MDA-MB-231 IC50
1.79 μM
Compound: 1b
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
SW480 IC50
8.9 μM
Compound: 1b
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
[PMID: 36092141]
分子量

366.46

Formula

C21H26N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BuChE-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BuChE-IN-62003213-07-6Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaIsatinOxindole1,2,3-triazoleButyrylcholinesteraseβ-amyloid inhibitionHepatotoxicityNeurotoxicityInhibitorinhibitorinhibit

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目录号：
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