GPR153 - G protein-coupled receptor 153 Gene

中文名称：G 蛋白偶联受体 153

种属: Homo sapiens

同用名: PGR1

关于 GPR153

功能概要

该基因编码一种完整的膜蛋白，属于 G 蛋白偶联受体的 A 类视紫红质超家族。编码的蛋白质主要在中枢神经系统中表达。大鼠直系同源基因的敲低与食物摄入量的显着减少和决策能力受损有关。该基因的突变与精神分裂症、自闭症和其他神经精神疾病有关。该基因的表达被神经胶质瘤相关致癌基因同系物 1 转录因子激活，而后者又被正常和致瘤细胞中的 sonic Hedgehog 激活。[RefSeq 提供，2017 年 2 月]

This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and Other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic Hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]