1. Gene
  2. SLC9A4 - solute carrier family 9 member A4 Gene

SLC9A4 - solute carrier family 9 member A4 Gene

中文名称:溶质载体家族 9 成员 A4

种属: Homo sapiens

同用名: NHE4

基因 ID: 389015 | 基因类型: protein coding

关于 SLC9A4

Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38): 2:102,473,226-102,533,972 (from NCBI)

This gene has 2 transcripts (splice variants), 134 orthologues and 10 paralogues. Biased expression in stomach (RPKM 24.9) and kidney (RPKM 5.2).

功能概要

预计会启用钾:质子反向转运活性和钠:质子反向转运活性。预计参与钾离子跨膜转运;调节细胞内 pH 值;和钠离子跨质膜输入。预测作用于上皮细胞发育和胃酸分泌的上游或内部。预计位于多个细胞成分中,包括顶端质膜;基底外侧质膜;和液泡膜。预计是膜的组成部分。预计在质膜上有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within epithelial cell development and gastric acid secretion. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and vacuolar membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC9A4 基因产物(1)

mRNA Protein Name
NM_001011552.4 NP_001011552.2 sodium/hydrogen exchanger 4 precursor

SLC9A4 蛋白结构

Na_H_Exchanger

Na_H_Exchanger: Sodium/hydrogen exchanger family (74 - 476)

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  • 798 a.a.
蛋白主名 其他名称

sodium/hydrogen exchanger 4

NHE-4

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLC9A4 VGNC VGNC:34943
Mus musculus SLC9A4 MGD MGI:105074
Felis catus SLC9A4 VGNC VGNC:65435
Macaca mulatta SLC9A4 VGNC VGNC:77641
Rattus norvegicus SLC9A4 RGD RGD:3721
Canis familiaris SLC9A4 VGNC VGNC:108217