2. Gene
  3. LPO - lactoperoxidase Gene

LPO - lactoperoxidase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乳过氧化物酶

种属: Homo sapiens

同用名: SPO

基因 ID: 4025 | 基因类型: protein coding

关于 LPO

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,238,584-58,268,518 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 5 paralogues. Restricted expression toward salivary gland (RPKM 211.8).

功能概要

该基因编码过氧化物酶蛋白质家族的成员。编码的前原蛋白经过蛋白水解处理以产生成熟酶。在从唾液腺、乳腺和其他粘膜腺分泌后，这种酶催化抗菌物质次硫氰酸的产生。该基因存在于 17 号染色体上的一个基因簇中。可变剪接导致多个转录物变体，其中至少一个变体编码一种经过蛋白水解处理的前原蛋白。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. Following its secretion from salivary, mammary, and Other mucosal glands, this Enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

LPO 基因产物(2)

mRNA Protein Name
NM_001160102.2 NP_001153574.1 lactoperoxidase isoform 3 preproprotein
NM_006151.3 NP_006142.1 lactoperoxidase isoform 1 preproprotein

LPO 蛋白结构

An_peroxidase

An_peroxidase: Animal haem peroxidase (138 - 684)

  • 0
  • 200
  • 400
  • 600
  • 712 a.a.
蛋白主名 其他名称

lactoperoxidase

salivary peroxidase

关联疾病

疾病名称 别名
Gingivitis

Chronic Gingivitis

Acute Gingivitis
Aplasia Of Lacrimal And Salivary Glands

ALSG

Congenital Absence Of Lacrimal Puncta And Salivary Glands

Xerostomia

Absence Of Salivary Glands

Parotid Aplasia Or Hypoplasia

Congenital Absence Of Lacrimal Puncta Or Salivary Glands

Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation
Mastitis

Breast Inflammation

Inflammatory Breast Disease

Inflammatory Disease Of Breast

Inflammation Of Non-Human Mammary Gland

Inflammatory Disorder Of Breast

Mastitis Nos

Acute Mastitis Nos

Acute Nonpuerperal Mastitis

Nonpuerperal Mastitis Nos

Subacute Mastitis Nos
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Developmental And Epileptic Encephalopathy 75

DEE75

Epileptic Encephalopathy, Early Infantile, 75

Eiee75

Developmental And Epileptic Encephalopathy, 75

Early Infantile Epileptic Encephalopathy 75
Gingival Disease

Gingival Diseases

Gum Disease

Gingival Disorder

Gingivitis And Periodontal Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141809 GPX4-IN-3 99.90% 否
HY-N12445 Quercetin-3'-O-glucoside 98.48% 否
HY-113455 9S-HODE Inducer / 否
HY-161388 NSCLC-IN-1 Inducer / 否
HY-161460 Ferroptosis-IN-7 Inhibitor / 否
HY-RS07773 LPO Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-101579 LY 178002 / 否
HY-113455S1 9(S)-HODE-13C18 Inducer / 否
HY-100148 ICI 211965 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LPO VGNC VGNC:74440
Rattus norvegicus LPO RGD RGD:1310051
Bos taurus LPO VGNC VGNC:30970
Felis catus LPO VGNC VGNC:68083
Mus musculus LPO MGD MGI:1923363
Canis familiaris LPO VGNC VGNC:42755
Others LPO NCBI
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