1. Gene
  2. CD180 - CD180 molecule Gene

CD180 - CD180 molecule Gene

中文名称:CD180 分子

种属: Homo sapiens

同用名: LY64; Ly78; RP105

基因 ID: 4064 | 基因类型: protein coding

关于 CD180

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:67,179,613-67,196,799 (from NCBI)

This gene has 2 transcripts (splice variants), 128 orthologues and 22 paralogues. Biased expression in lymph node (RPKM 23.1), spleen (RPKM 12.8) and 10 other tissues.

功能概要

CD180 是一种细胞表面分子,由细胞外富含亮氨酸重复序列 (LRR) 和短胞质尾组成。细胞外 LRR 与称为 MD-1 的分子相关,并形成细胞表面受体复合物 RP105/MD-1。它属于病原体受体家族,即 Toll 样受体 (TLR) 。 RP105/MD1 通过与 TLR4 协同工作,控制 B 细胞识别和脂多糖 (LPS) 的信号传导,脂多糖是革兰氏阴性菌的一种膜成分。[RefSeq 提供,2008 年 7 月]

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

CD180 基因产物(1)

mRNA Protein Name
NM_005582.3 NP_005573.2 CD180 antigen precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21857663 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway IGI
IGI: 通过遗传相互作用推断
10880523 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD180 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (78 - 135)

LRR_8

LRR_8: Leucine rich repeat (345 - 407)

LRR_8

LRR_8: Leucine rich repeat (420 - 481)

LRR_8

LRR_8: Leucine rich repeat (497 - 544)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
蛋白主名 其他名称

CD180 antigen

lymphocyte antigen 64

CD180 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD180 Q99467 LY86 Homo sapiens O95711
Pull Down
21857663
种属内
CD180 Q99467 LY86 Homo sapiens O95711
GMS
21857663
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD180 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77181 RP105/CD180 Protein, Human (HEK293, His) Q99467/NP_005573.2 (W24-G626) ≥95%

关联疾病

疾病名称 别名
Retinitis Pigmentosa 85

RP85

Retinitis Pigmentosa, Type 85

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Retinitis Pigmentosa 74

RP74

Retinitis Pigmentosa, Type 74

Brachydactyly, Type C

Brachydactyly Type C

BDC

Brachydactyly Haws Type

Brachydactyly, Haws Type

Brachydactyly C

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CD180 VGNC VGNC:102176
Mus musculus CD180 MGD MGI:1194924
Macaca mulatta CD180 VGNC VGNC:70929
Bos taurus CD180 VGNC VGNC:52748
Canis familiaris CD180 VGNC VGNC:52119
Rattus norvegicus CD180 RGD RGD:1308170
Others CD180 NCBI