1. Gene
  2. ART1 - ADP-ribosyltransferase 1 Gene

ART1 - ADP-ribosyltransferase 1 Gene

中文名称:ADP-核糖基转移酶 1

种属: Homo sapiens

同用名: RT6; ART2; ARTC1; CD296

基因 ID: 417 | 基因类型: protein coding

关于 ART1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,645,128-3,664,416 (from NCBI)

This gene has 2 transcripts (splice variants), 652 orthologues and 3 paralogues. Low expression observed in reference dataset.

功能概要

ADP-核糖基转移酶催化蛋白质中精氨酸残基的 ADP-核糖基化。单-ADP-核糖基化是一种蛋白质翻译后修饰,会受到多种细菌毒素的干扰,包括霍乱、百日咳和大肠杆菌的不耐热肠毒素。氨基酸序列主要由疏水性 N 端和 C 端区域组成,这是糖基磷脂酰肌醇 (GPI) 锚定蛋白的特征。该基因以前被命名为 ART2。[RefSeq 提供,2008 年 7 月]

ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of Bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

ART1 基因产物(1)

mRNA Protein Name
NM_004314.3 NP_004305.2 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

ART1 蛋白结构

ART

ART: NAD:arginine ADP-ribosyltransferase (39 - 274)

  • 0
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  • 200
  • 300
  • 327 a.a.
蛋白主名 其他名称

GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

ADP-ribosyltransferase 2

关联疾病

疾病名称 别名
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8

Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly

Lateral Myocardial Infarction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ART1 MGD MGI:107511
Felis catus ART1 VGNC VGNC:68316
Canis familiaris ART1 VGNC VGNC:38147
Rattus norvegicus ART1 RGD RGD:1304591
Macaca mulatta ART1 VGNC VGNC:70024
Macaca fascicularis ART1 NCBI NCBI:102142531
Others ART1 NCBI