2. Gene
  3. CNOT4 - CCR4-NOT transcription complex subunit 4 Gene

CNOT4 - CCR4-NOT transcription complex subunit 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CCR4-NOT 转录复合物亚基 4

种属: Homo sapiens

同用名: NOT4; NOT4H; CLONE243

基因 ID: 4850 | 基因类型: protein coding

关于 CNOT4

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,361,795-135,510,102 (from NCBI)

This gene has 11 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in testis (RPKM 8.1), brain (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是 CCR4-NOT 复合体的一个亚基，CCR4-NOT 复合体是一种全局转录调节因子。编码的蛋白质与 CNOT1 相互作用并具有 E3 泛素连接酶活性。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2010 年 7 月]

The protein encoded by this gene is a subunit of the CCR4-NOT complex, a global transcriptional regulator. The encoded protein interacts with CNOT1 and has E3 ubiquitin Ligase activity. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

CNOT4 基因产物(12)

mRNA Protein Name
NM_001008225.3 NP_001008226.1 CCR4-NOT transcription complex subunit 4 isoform b
NM_001190847.2 NP_001177776.1 CCR4-NOT transcription complex subunit 4 isoform c
NM_001190848.2 NP_001177777.1 CCR4-NOT transcription complex subunit 4 isoform d
NM_001190849.2 NP_001177778.1 CCR4-NOT transcription complex subunit 4 isoform e
NM_001190850.2 NP_001177779.1 CCR4-NOT transcription complex subunit 4 isoform f
NM_001393370.1 NP_001380299.1 CCR4-NOT transcription complex subunit 4 isoform f
NM_001393371.1 NP_001380300.1 CCR4-NOT transcription complex subunit 4 isoform g
NM_001393372.1 NP_001380301.1 CCR4-NOT transcription complex subunit 4 isoform h
NM_001393373.1 NP_001380302.1 CCR4-NOT transcription complex subunit 4 isoform i
NM_001393374.1 NP_001380303.1 CCR4-NOT transcription complex subunit 4 isoform a
NM_001393375.1 NP_001380304.1 CCR4-NOT transcription complex subunit 4 isoform k
NM_013316.4 NP_037448.2 CCR4-NOT transcription complex subunit 4 isoform a

CNOT4 蛋白结构

zf-RING_4

zf-RING_4: RING/Ubox like zinc-binding domain (14 - 60)

RRM_5

RRM_5: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (130 - 189)

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  • 575 a.a.
蛋白主名 其他名称

CCR4-NOT transcription complex subunit 4

CCR4-associated factor 4

关联疾病

疾病名称 别名
Adenoiditis

Chronic Adenoiditis
Brachydactyly, Type E2

Brachydactyly Type E2

BDE2

Brachydactyly E2
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02904 CNOT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CNOT4 RGD RGD:1310318
Mus musculus CNOT4 MGD MGI:1859026
Canis familiaris CNOT4 VGNC VGNC:39415
Macaca mulatta CNOT4 VGNC VGNC:71389
Felis catus CNOT4 VGNC VGNC:68518
Bos taurus CNOT4 VGNC VGNC:27519
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