Pten - phosphatase and tensin homolog Gene

中文名称：磷酸酶和张力蛋白同系物

种属: Rattus norvegicus

同用名: Mmac; TEP1; MMAC1

关于 Pten

功能概要

该基因编码的蛋白可启动多项功能，包括 PDZ 域绑定活动；磷脂酰肌醇-3,4,5-三磷酸 3-磷酸酶活性；和信号受体结合活性。参与多个过程，包括细胞对激素刺激的反应；去磷酸化；和运输的负面监管。位于多个细胞成分中，包括树突棘；线粒体；和突触后膜。在突触后细胞质中活跃。用于研究门静脉高压症和物质相关疾病。多种疾病的生物标志物，包括急性心肌梗塞；脂肪肝病；糖代谢疾病（多种）；视网膜疾病（多发）；和短暂性脑缺血。该基因的人类直系同源物与多种疾病有关，包括 PTEN 错构瘤肿瘤综合征（多种）；乳腺癌（多发性）；胃肠系统癌症（多发性）；神经系统癌症（多发性）；和生殖器官癌（多发性）。与人类 PTEN 同源（磷酸酶和张力蛋白同系物）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including PDZ domain binding activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; dephosphorylation; and negative regulation of transport. Located in several cellular components, including dendritic spine; mitochondrion; and postsynaptic membrane. Is active in postsynaptic cytosol. Used to study portal hypertension and substance-related disorder. Biomarker of several diseases, including acute myocardial infarction; fatty liver disease; glucose metabolism disease (multiple); retinal disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast Cancer (multiple); gastrointestinal system Cancer (multiple); nervous system Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human PTEN (Phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Apr 2022]