bpV(phen) trihydrate 

bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity^{[1][2][3][4][5]}.

bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理导致 H/R 损伤的 H9c2 细胞的细胞活力进一步降低^[1]。
bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理增加 H/R 损伤的 H9c2 细胞的凋亡^[1]。
bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理显著促进 H/R 损伤的 H9c2 细胞中细胞质细胞色素 C 的积累^[1]。
用 bpV (phen) 刺激后，PTEN 诱导的推定激酶蛋白 1 (PINK1)/Parkin 介导的线粒体自噬受到抑制^[1]。
bpV (phen) 是胰岛素受体酪氨酸激酶过度磷酸化和激活后的胰岛素模拟剂^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

bpV (phen) (5 mg/kg；腹膜内注射；每天；持续 38 天；雄性 BALB/c 裸 (nu/nu) 无胸腺小鼠) 处理导致平均肿瘤体积显著减小^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

404.29

C₁₂H₁₄KN₂O₈V

171202-16-7

固体

Yellow to orange

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55(9):741-748.  [Content Brief]

  [2]. Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262(2):265-75.  [Content Brief]

  [3]. Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566(1-3):35-8.  [Content Brief]

  [4]. Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen). Mol Endocrinol. 1997 Dec;11(13):1899-910.  [Content Brief]

  [5]. Chen Q, et al. Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290(43):26051-8.  [Content Brief]