1. Gene
  2. A4GNT - alpha-1,4-N-acetylglucosaminyltransferase Gene

A4GNT - alpha-1,4-N-acetylglucosaminyltransferase Gene

中文名称:α-1,4-N-乙酰葡糖胺基转移酶

种属: Homo sapiens

同用名: alpha4GnT

基因 ID: 51146 | 基因类型: protein coding

关于 A4GNT

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,123,713-138,133,302 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 1 paralogue. Biased expression in stomach (RPKM 9.5), duodenum (RPKM 0.9) and 1 other tissue.

功能概要

该基因编码一种来自糖基转移酶 32 家族的蛋白质。该酶催化 N-乙酰葡糖胺 (GlcNAc) 向核心 2 支链 O-聚糖的转移。它形成一个独特的聚糖,GlcNAcalpha1-->4Galbeta-->R,主要与高尔基体膜相关。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein from the Glycosyltransferase 32 family. The Enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]

A4GNT 基因产物(1)

mRNA Protein Name
NM_016161.3 NP_057245.1 alpha-1,4-N-acetylglucosaminyltransferase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylglucosaminyltransferase activity IDA
IDA: 通过直接分析推断
10430883 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within glycoprotein biosynthetic process IDA
IDA: 通过直接分析推断
10430883 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

A4GNT 蛋白结构

Gly_transf_sug

Gly_transf_sug: Glycosyltransferase sugar-binding region containing DXD motif (64 - 179)

Gb3_synth

Gb3_synth: Alpha 1,4-glycosyltransferase conserved region (196 - 323)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
蛋白主名 其他名称

alpha-1,4-N-acetylglucosaminyltransferase

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta A4GNT VGNC VGNC:81171
Bos taurus A4GNT VGNC VGNC:25436
Felis catus A4GNT VGNC VGNC:59446
Rattus norvegicus A4GNT RGD RGD:1590210
Canis familiaris A4GNT VGNC VGNC:37401
Mus musculus A4GNT MGD MGI:2143261