KDM3B - lysine demethylase 3B Gene

中文名称：赖氨酸脱甲基酶 3B

种属: Homo sapiens

同用名: 5qNCA; DIJOS; NET22; C5orf7; JMJD1B

基因 ID: 51780 | 基因类型: protein coding

关于 KDM3B

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,352,685-138,437,027 (from NCBI)

This gene has 9 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 15.2), thyroid (RPKM 13.7) and 25 other tissues.

功能概要

预测启用染色质 DNA 结合活性；组蛋白 H3-甲基-赖氨酸-9 脱甲基酶活性；和转录共调节因子活性。预测参与组蛋白 H3-K9 去甲基化和 RNA 聚合酶 II 的转录调控。位于核质中。急性淋巴细胞白血病生物标志物；乳腺癌;结直肠癌；和肺非小细胞癌。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chromatin DNA binding activity; histone H3-methyl-lysine-9 demethylase activity; and transcription coregulator activity. Predicted to be involved in histone H3-K9 demethylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of acute lymphoblastic leukemia; breast cancer; colorectal cancer; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM3B 基因产物(1)

mRNA	Protein	Name
NM_016604.4	NP_057688.3	lysine-specific demethylase 3B

KDM3B 蛋白结构

JmjC

0
300
600
900
1200
1500
1761 a.a.

蛋白主名

其他名称

lysine-specific demethylase 3B

[histone H3]-dimethyl-L-lysine(9) demethylase 3B

重组 KDM3B 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71585	KDM3B Protein, Human (Myc, His-SUMO)	Q7LBC6-1 (M1498-R1721)	≥95%

关联疾病

疾病名称

别名

Diets-Jongmans Syndrome

DIJOS	Intellectual Developmental Disorder With Distinctive Facial Dysmorphism
Iddfd

Rare Genetic Epilepsy

Rare Genetic Intellectual Disability

Otopalatodigital Syndrome, Type I

Otopalatodigital Syndrome Type 1	Taybi Syndrome
OPD1	Opd Syndrome 1
Oto-Palato-Digital Syndrome Type 1	Opd I Syndrome
Oto-Palato-Digital Syndrome, Type I	Otopalatodigital Syndrome Type I
Opd Syndrome	Cranioorodigital Syndrome
Faciopalatoosseous Syndrome	Fpo
Opd Syndrome, Type 1	Otopalatodigital Syndrome 1

Hereditary Wilms' Tumor

Hereditary Wilms Tumor	Hereditary Wilms Tumour
Hereditary Wilms' Tumour	Wt1

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Adult Medulloblastoma

Adult Brain Medulloblastoma

Medulloblastoma, Adult

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-139348	PFI-90		99.86%	否
HY-162301	P3FI-63	Inhibitor	98.35%	否
HY-168593	Wnt/β-catenin-IN-5		/	否
HY-RS07212	KDM3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	KDM3B	VGNC	VGNC:63071
Rattus norvegicus	KDM3B	RGD	RGD:1583423
Bos taurus	KDM3B	VGNC	VGNC:30526
Canis familiaris	KDM3B	VGNC	VGNC:42323
Mus musculus	KDM3B	MGD	MGI:1923356
Macaca mulatta	KDM3B	VGNC	VGNC:73823
Others	KDM3B	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KDM3B - lysine demethylase 3B Gene

关于 KDM3B

功能概要

KDM3B 基因产物(1)

KDM3B 蛋白结构

重组 KDM3B 蛋白

关联疾病

直系同源

热门区域

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KDM3B - lysine demethylase 3B Gene

关于 KDM3B

功能概要

KDM3B 基因产物(1)

KDM3B 蛋白结构

重组 KDM3B 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z