POLR2F - RNA polymerase II, I and III subunit F Gene

中文名称：RNA 聚合酶 II、I 和 III 亚基 F

种属: Homo sapiens

同用名: RPB6; POLRF; RPC15; RPABC2; RPB14.4; HRBP14.4; RPABC14.4

基因 ID: 5435 | 基因类型: protein coding

关于 POLR2F

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,953,663-38,041,915 (from NCBI)

This gene has 14 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 8.9), kidney (RPKM 5.0) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 的第六大亚基，该聚合酶负责在真核生物中合成信使 RNA。在酵母中，该聚合酶亚基与至少两个其他亚基结合，形成一种结构，可稳定 DNA 模板上的转录聚合酶。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two Other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

POLR2F 基因产物(5)

mRNA	Protein	Name
NM_001301129.2	NP_001288058.1	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 2
NM_001301130.2	NP_001288059.1	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 3
NM_001301131.2	NP_001288060.1	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 4
NM_001363825.1	NP_001350754.1	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 5
NM_021974.5	NP_068809.1	DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform 1

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9852112	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase I complex	IDA IDA: 通过直接分析推断	34671025	GOA
part of RNA polymerase II, core complex	IDA IDA: 通过直接分析推断	9852112	GOA
part of RNA polymerase III complex	IDA IDA: 通过直接分析推断	33335104	GOA
located in nucleus	IDA IDA: 通过直接分析推断	9852112	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLR2F 蛋白结构

RNA_pol_Rpb6

0
100
127 a.a.

蛋白主名

其他名称

DNA-directed RNA polymerases I, II, and III subunit RPABC2

DNA-directed RNA polymerase II subunit F

关联疾病

疾病名称

别名

Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease

Pcwh Syndrome	PCWH
Neurologic Waardenburg-Shah Syndrome	Waardenburg-Shah Syndrome, Neurologic Variant
Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Hirschsprung Disease-Waardenburg Syndrome	Peripheral Demyelinating Neuropathy-Central Dysmyelinating Leukodystrophy-Waardenburg Syndrome-Hirschsprung Disease
Ws4 Plus	Peripheral Demyelinating Neuropathy, Central Dysmyelinating Leukodystrophy, Waardenburg Syndrome And Hirschsprung Disease
Waardenburg-Shah Syndrome Neurologic Variant

Waardenburg Syndrome, Type 4c

Waardenburg Syndrome Type 4c	WS4C
Waardenburg Syndrome Type Ivc	Waardenburg Syndrome With Hirschsprung Disease Type 4c
Waardenburg Syndrome With Hirschsprung Disease, Type 4c	Waardenburg Syndrome, Type Ivc
Waardenburg Syndrome 4c	Hirschsprung Disease With Pigmentary Anomaly
Shah-Waardenburg Syndrome	Waardenburg-Shah Syndrome
Waardenburg Syndrome, Type 4a

Waardenburg Syndrome, Type 2e

Waardenburg Syndrome Type 2	Waardenburg Syndrome Type 2e
WS2E	Waardenburg Syndrome, Type 2e, With Or Without Neurologic Involvement
Waardenburg Syndrome, Type Iie	Hypogonadotropic Hypogonadism With Anosmia And Deafness With Or Without Hypopigmentation
Waardenburg Syndrome Type 2e With Or Without Neurologic Involvement	Waardenburg Syndrome Type Iie
Hypogonadotropic Hypogonadism With Anosmia And Deafness, With Or Without Hypopigmentation	Ws2e, With Or Without Neurologic Involvement
Ws2e With Or Without Neurological Involvement	Ws 2
Ws Type 2	Ws2
Waardenburg Syndrome Type Ii	Waardenburg Syndrome 2e
Kallmann Syndrome And Deafness With Or Without Hypopigmentation	Ws2e With Or Without Neurologic Involvement
Waardenburg Syndrome Type 2e, Without Neurologic Involvement	Ws-2

Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1	WS1
Waardenburg Syndrome Type I	Waardenburg Syndrome With Dystopia Canthorum
Waardenburg'S Syndrome Type 1	Waardenburg Syndrome 1
Waardenburg Syndrome, Type I	Waardenburg Syndrome

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Rare Genetic Deafness

Rare Genetic Hearing Loss

Waardenburg Syndrome, Type 2a

Waardenburg Syndrome Type 2a	WS2A
Waardenburg Syndrome, Type Iia	Waardenburg Syndrome Without Dystopia Canthorum
Ws2	Waardenburg Syndrome Type Iia
Waardenburg Syndrome 2a

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy	CNM1
Centronuclear Myopathy 1	Ad-Cnm
Myopathy, Centronuclear, Autosomal Dominant	Myotubular Myopathy, Autosomal Dominant
Centronuclear Myopathy, Autosomal, Modifier Of	Autosomal Dominant Myotubular Myopathy
Dnm2-Related Centronuclear Myopathy	Centronuclear Myopathy Autosomal Dominant
Myopathies, Structural, Congenital	Myopathy, Centronuclear, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10847	POLR2F Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	POLR2F	VGNC	VGNC:44797
Bos taurus	POLR2F	VGNC	VGNC:33140
Macaca mulatta	POLR2F	VGNC	VGNC:97120
Mus musculus	POLR2F	MGD	MGI:1349393
Rattus norvegicus	POLR2F	RGD	RGD:708567
Felis catus	POLR2F	VGNC	VGNC:68951

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLR2F - RNA polymerase II, I and III subunit F Gene

关于 POLR2F

功能概要

POLR2F 基因产物(5)

POLR2F 蛋白结构

关联疾病

直系同源

热门区域

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POLR2F - RNA polymerase II, I and III subunit F Gene

关于 POLR2F

功能概要

POLR2F 基因产物(5)

POLR2F 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z