1. Gene
  2. ROBO4 - roundabout guidance receptor 4 Gene

ROBO4 - roundabout guidance receptor 4 Gene

中文名称:环岛引导接收器 4

种属: Homo sapiens

同用名: MRB; AOVD3; ECSM4

基因 ID: 54538 | 基因类型: protein coding

关于 ROBO4

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,883,691-124,897,865 (from NCBI)

This gene has 10 transcripts (splice variants), 99 orthologues, 36 paralogues and is associated with 2 phenotypes. Broad expression in fat (RPKM 35.9), spleen (RPKM 32.4) and 17 other tissues.

功能概要

预测可启用细胞间粘附介体活性。参与血管生成和内皮屏障的建立。位于细胞外外泌体。涉及主动脉瓣疾病 3。[由基因组资源联盟提供,2022 年 4 月]

Predicted to enable cell-cell adhesion mediator activity. Involved in angiogenesis and establishment of endothelial barrier. Located in extracellular exosome. Implicated in aortic valve disease 3. [provided by Alliance of Genome Resources, Apr 2022]

ROBO4 基因产物(2)

mRNA Protein Name
NM_001301088.2 NP_001288017.1 roundabout homolog 4 isoform 2
NM_019055.6 NP_061928.4 roundabout homolog 4 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in establishment of endothelial barrier IMP
IMP: 通过突变表型推断
30455415 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ROBO4 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (32 - 124)

I-set

I-set: Immunoglobulin I-set domain (138 - 220)

fn3

fn3: Fibronectin type III domain (350 - 432)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1007 a.a.
蛋白主名 其他名称

roundabout homolog 4

roundabout homolog 4, magic roundabout

重组 ROBO4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71262 ROBO4 Protein, Human (HEK293, Fc) Q8WZ75-1 (Q28-R467) ≥95%
HY-P76009 ROBO4 Protein, Human (HEK293, His) Q8WZ75-1 (Q28-R467) ≥95%

关联疾病

疾病名称 别名
Aortic Valve Disease 3

AOVD3

Aortic Valve Disease 1

Aortic Valve Disease

Bicuspid Aortic Valve

Aortic Valve Disorder

AOVD1

Bav

Bicuspid Aortic Valve Disease

Familial Bicuspid Aortic Valve

Aortic Valve Calcification

Aovd

Aortic Valve, Bicuspid

Aortic Valve, Calcification Of

Aortic Stenosis, Calcific

Familial Bav

Calcific Aortic Stenosis

Calcification Of Aortic Valve

Abnormality Of The Aortic Valve

Aortic Valve Disease, Type 1

Aortic Valve Disease 2

Bicommissural Aortic Valve

Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect

Aortic Aneurysm

Aortic Rupture

Thoracoabdominal Aortic Aneurysm, Ruptured

Ruptured Aortic Aneurysm

Aortic Aneurysms

Aortic Aneurysm Without Mention Of Rupture Nos

Ruptured Abdominal Aortic Aneurysm

Aortic Aneurysm, Ruptured

Ruptured Thoracic Aortic Aneurysm

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Familial Thoracic Aortic Aneurysm

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta

Corneal Neovascularization

Corneal Neovascularisation

Corneal Vascularisation

Extensive Superficial Corneal Vascularisation

Hypoplastic Left Heart Syndrome

Hlhs

Heart, Hypoplastic Left, Syndrome

Hypoplasia Of The Left Heart

Left Heart Hypoplasia Syndrome

Hlhs - [Hypoplastic Left Heart Syndrome]

Hypoplasia Of Aortic Valve, In Hypoplastic Left Heart Syndrome

Atresia Of Mitral Valve, In Hypoplastic Left Heart Syndrome

Atresia Or Marked Hypoplasia Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle

Atresia Or Marked Hypoplasia, Of Aortic Orifice Or Valve, With Hypoplasia Of Ascending Aorta And Defective Development Of Left Ventricle With Mitral Valve Atresia

Aortic Valve Atresia, In Hypoplastic Left Heart Syndrome

Ascending Aorta Hypoplasia, In Hypoplastic Left Heart Syndrome

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2a

MLC2A

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, 2a

Leukoencephalopathy, Megalencephalic, With Subcortical Cysts, Type 2a

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b

Megalencephalic Leukoencephalopathy With Subcortical Cysts 2b, Remitting, With Or Without Mental Retardation

Hantavirus Pulmonary Syndrome

Hps

Four Corners Hantavirus

Hards

Hantavirus

Hantavirus-Associated Respiratory Distress Syndrome

Hanta Virus

Hantavirus Cardiopulmonary Syndrome

Hps - [Hantavirus Pulmonary Syndrome]

Hcps - [Hantavirus Cardiopulmonary Syndrome]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus ROBO4 VGNC VGNC:34081
Rattus norvegicus ROBO4 RGD RGD:6494870
Mus musculus ROBO4 MGD MGI:1921394
Canis familiaris ROBO4 VGNC VGNC:45687
Macaca mulatta ROBO4 VGNC VGNC:76760
Felis catus ROBO4 VGNC VGNC:81954
Others ROBO4 NCBI