PRB4 - proline rich protein BstNI subfamily 4 Gene

中文名称：富脯氨酸蛋白 BstNI 亚家族 4

种属: Homo sapiens

同用名: Po

关于 PRB4

功能概要

该基因编码基本的、富含脯氨酸的人类唾液糖蛋白异质家族的成员。编码的前原蛋白在从腮腺分泌之前经过蛋白水解加工以产生一种或多种成熟肽。已经鉴定出该基因的多个等位基因在串联重复序列的长度上表现出变化。参考基因组编码“小”等位基因。该基因位于 12 号染色体上的一组密切相关的富含脯氨酸的唾液蛋白中。可变剪接导致编码不同亚型的多个转录变体，这些亚型可能经历类似的蛋白水解加工。[RefSeq 提供，2015 年 11 月]

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature Peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the "Small" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]