PRSS2 - serine protease 2 Gene

中文名称：丝氨酸蛋白酶 2

种属: Homo sapiens

同用名: TRY2; TRY8; TRYP2

关于 PRSS2

功能概要

该基因属于丝氨酸蛋白酶的胰蛋白酶家族，编码阴离子胰蛋白酶原。它是位于 T 细胞受体 β 基因座内的一组胰蛋白酶原基因的一部分。该家族的酶切割赖氨酸或精氨酸残基后的肽键。这种蛋白质在胰液中含量很高，其上调是胰腺炎的一个特征。还发现这种蛋白质可以激活卵巢肿瘤中的尿激酶原，表明它在肿瘤侵袭中发挥作用。此外，这种酶能够切割类风湿性关节炎滑膜炎组织中的 II 型胶原蛋白三螺旋，可能参与富含 II 型胶原蛋白的软骨基质的降解。可变剪接导致多个转录变体。[RefSeq 提供，2015 年 1 月]

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this Enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]