2. Gene
  3. TMPRSS15 - transmembrane serine protease 15 Gene

TMPRSS15 - transmembrane serine protease 15 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜丝氨酸蛋白酶 15

种属: Homo sapiens

同用名: ENTK; PRSS7

基因 ID: 5651 | 基因类型: protein coding

关于 TMPRSS15

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:18,269,116-18,460,676 (from NCBI)

This gene has 3 transcripts (splice variants), 146 orthologues, 17 paralogues and is associated with 2 phenotypes. Restricted expression toward duodenum (RPKM 404.7).

功能概要

该基因编码一种酶，可将胰酶原胰蛋白酶原转化为胰蛋白酶，从而激活其他酶原，包括胰凝乳蛋白酶原和羧肽酶原。前体蛋白被切割成两条链，形成通过二硫键连接的异二聚体。这种蛋白质是肽酶胰蛋白酶家族的成员。该基因的突变会导致肠激酶缺乏症，这是一种以腹泻和发育停滞为特征的吸收不良疾病。[RefSeq 提供，2008 年 7 月]

This gene encodes an Enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates Other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

TMPRSS15 基因产物(1)

mRNA Protein Name
NM_002772.3 NP_002763.3 enteropeptidase precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24407287 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMPRSS15 蛋白结构

SEA

SEA: SEA domain (58 - 157)

CUB

CUB: CUB domain (225 - 331)

MAM

MAM: MAM domain, meprin/A5/mu (347 - 503)

CUB

CUB: CUB domain (524 - 631)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (642 - 677)

SRCR_2

SRCR_2: Scavenger receptor cysteine-rich domain (695 - 774)

Trypsin

Trypsin: Trypsin (785 - 1014)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1019 a.a.
蛋白主名 其他名称

enteropeptidase

enterokinase catalytic subunit

关联疾病

疾病名称 别名
Enterokinase Deficiency

Enteropeptidase Deficiency

Congenital Enterokinase Deficiency

Congenital Enteropathy Due To Enteropeptidase Deficiency

Deficiency Of Enteropeptidase

ENTKD
Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Pancreatitis

Mumps Pancreatitis
Noonan Syndrome 8

NS8

Noonan Syndrome, Type 8
Hymenolepiasis

Dwarf Tapeworm Infection

Hymenolepis Infectious Disease

Hymenolepsis Infection

Hyemolepis Nana Infection

Hymenolepiosis

Hymenolepis Infection

Dwarf Tapeworm

Hymenolepidosis

Hymenolepis Infestation
Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases
Ciliary Dyskinesia, Primary, 26

Primary Ciliary Dyskinesia 26

CILD26

Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, 26
Developmental And Epileptic Encephalopathy 53

DEE53

Epileptic Encephalopathy, Early Infantile, 53

Eiee53

Developmental And Epileptic Encephalopathy, 53

Early Infantile Epileptic Encephalopathy 53
Acute Necrotizing Pancreatitis

Pancreatitis, Acute Necrotizing
Psoriasis 11

PSORS11

Psoriasis Susceptibility 11

Psoriasis

Psoriasis Vulgaris

Psoriasis 11, Susceptibility To

Pv
Acute Hemorrhagic Pancreatitis

Pancreatitis, Acute Hemorrhagic
Lactase Deficiency, Congenital

Congenital Lactase Deficiency

Disaccharide Intolerance Ii

Congenital Alactasia

Congenital Alactasia Syndrome

Congenital Lactose Intolerance

Congenital Lactose Malabsorption

Hereditary Alactasia

Alactasia, Congenital

Cld

COLACD

Disaccharide Intolerance Type 2

Cld - [Congenital Lactase Deficiency]

Disaccharide Intolerance 2

Lactose Intolerance Of Newborn

Hereditary Lactase Deficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2990 Enteropeptidase / 否
HY-RS14768 TMPRSS15 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TMPRSS15 VGNC VGNC:36139
Canis familiaris TMPRSS15 VGNC VGNC:47632
Macaca mulatta TMPRSS15 VGNC VGNC:108449
Rattus norvegicus TMPRSS15 RGD RGD:1311046
Mus musculus TMPRSS15 MGD MGI:1197523
Felis catus TMPRSS15 VGNC VGNC:69091
Others TMPRSS15 NCBI
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