PSG3 - pregnancy specific beta-1-glycoprotein 3 Gene

中文名称：妊娠特异性 β-1-糖蛋白 3

种属: Homo sapiens

关于 PSG3

功能概要

人类妊娠特异性糖蛋白 (PSG) 是一个由胎盘滋养细胞大量合成并在妊娠期间释放到母体循环中的蛋白质家族。几个 PSG 基因的分子克隆和分析表明，PSG 形成癌胚抗原 (CEA) 基因家族的一个亚组，属于免疫球蛋白基因超家族。 CEA 家族的成员由一个 N 结构域组成，其结构与免疫球蛋白可变结构域相似，随后是数量可变的免疫球蛋白恒定样 A 和/或 B 结构域。大多数 PSG 具有 arg-gly-asp (RGD) 基序，它已被证明在 N 末端结构域中充当多种整合素的粘附识别信号 (Teglund 等人总结，1994 [PubMed 7851896]) 。有关 PSG 基因家族的其他一般信息，请参阅 PSG1 (MIM 176390) 。[OMIM 提供，2009 年 10 月]

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]