2. Gene
  3. PTPRH - protein tyrosine phosphatase receptor type H Gene

PTPRH - protein tyrosine phosphatase receptor type H Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：H 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: SAP1; R-PTP-H

基因 ID: 5794 | 基因类型: protein coding

关于 PTPRH

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,181,247-55,209,501 (from NCBI)

This gene has 7 transcripts (splice variants), 81 orthologues and 35 paralogues. Biased expression in small intestine (RPKM 32.9), duodenum (RPKM 31.2) and 7 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和单个胞质内催化结构域，因此代表受体型 PTP。细胞外区域包含八个 III 型纤连蛋白样重复序列和多个 N-糖基化位点。该基因被证明主要在大脑和肝脏中表达，在心脏和胃中的表达水平较低。还发现它在几种癌细胞系中表达，但不在相应的正常组织中表达。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 6 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several Cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

PTPRH 基因产物(2)

mRNA Protein Name
NM_001161440.3 NP_001154912.2 receptor-type tyrosine-protein phosphatase H isoform 2 precursor
NM_002842.5 NP_002833.4 receptor-type tyrosine-protein phosphatase H isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IPI
IPI: 通过物理相互作用推断
28926625 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12907755 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRH 蛋白结构

fn3

fn3: Fibronectin type III domain (31 - 100)

fn3

fn3: Fibronectin type III domain (121 - 187)

fn3

fn3: Fibronectin type III domain (210 - 278)

fn3

fn3: Fibronectin type III domain (299 - 366)

fn3

fn3: Fibronectin type III domain (388 - 462)

fn3

fn3: Fibronectin type III domain (477 - 551)

fn3

fn3: Fibronectin type III domain (568 - 650)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (844 - 1077)

  • 0
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  • 1115 a.a.
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase H

stomach cancer-associated protein tyrosine phosphatase 1

PTPRH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPRH Q9HD43 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
PTPRH Q9HD43 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
种属内
PTPRH Q9HD43 GHR Homo sapiens P10912
Array
12907755
种属内
PTPRH Q9HD43 GHR Homo sapiens P10912
Far-WB
12907755
种属内
PTPRH Q9HD43 EGFR Homo sapiens P00533
Anti Tag CoIP
28065597
种属内
PTPRH Q9HD43 DHPS Homo sapiens P49366
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Peutz-Jeghers Syndrome

PJS

Polyposis, Hamartomatous Intestinal

Polyps-And-Spots Syndrome

Lentiginosis, Perioral

Periorificial Lentiginosis Syndrome

Hamartomatous Intestinal Polyposis

Hamartomatous Polyp

Colonic Hamartomatous Polyp

Gastric Peutz-Jeghers Polyp

Peutz Jeghers Colon Polyp

Peutz Jeghers Polyp

Peutz-Jeghers Polyp Of Small Intestine

Peutz-Jeghers Small Bowel Hamartoma

Peutz Jeghers Polyposis

Intestinal Polyposis-Cutaneous Pigmentation Syndrome

Peutz-Jeghers Polyposis

Polyposis, Intestinal, Ii

Intestinal Hamartomatous Polyposis

Peutz-Jeghers Polyp

Peutz-Jeghers Polyp Of The Stomach

Peutz Jehgers Polyp

Peutz-Jeghers Polyps Of Small Bowel
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11440 PTPRH Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PTPRH VGNC VGNC:69174
Canis familiaris PTPRH VGNC VGNC:45189
Macaca mulatta PTPRH VGNC VGNC:76617
Mus musculus PTPRH MGD MGI:3026877
Bos taurus PTPRH VGNC VGNC:57057
Rattus norvegicus PTPRH RGD RGD:620553
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