1. Gene
  2. SIGIRR - single Ig and TIR domain containing Gene

SIGIRR - single Ig and TIR domain containing Gene

中文名称:含单个 Ig 和 TIR 结构域

种属: Homo sapiens

同用名: TIR8; IL-1R8

基因 ID: 59307 | 基因类型: protein coding

关于 SIGIRR

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:405,716-417,397 (from NCBI)

This gene has 22 transcripts (splice variants), 176 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues.

功能概要

预测启用 NAD+ 核苷酶活性。参与 DNA 结合转录因子活性的负调控。位于膜内。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGIRR 基因产物(3)

mRNA Protein Name
NM_001135053.2 NP_001128525.1 single Ig IL-1-related receptor
NM_001135054.2 NP_001128526.1 single Ig IL-1-related receptor
NM_021805.3 NP_068577.2 single Ig IL-1-related receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12925853 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Toll signaling pathway IMP
IMP: 通过突变表型推断
12925853 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IMP
IMP: 通过突变表型推断
10346978 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SIGIRR 蛋白结构

TIR

TIR: TIR domain (167 - 303)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
蛋白主名 其他名称

single Ig IL-1-related receptor

single Ig IL-1R-related molecule

SIGIRR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIGIRR Q6IA17 PALM3 Homo sapiens A6NDB9
Y2H
21187075
种属内
SIGIRR Q6IA17 PALM3 Homo sapiens A6NDB9
Anti Tag CoIP
21187075
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SIGIRR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76064 SIGIRR Protein, Human (HEK293, Fc) Q6IA17-1 (M1-H118) ≥95%
HY-P76065 SIGIRR Protein, Human (HEK293, His) Q6IA17 (M1-H118) ≥95%

关联疾病

疾病名称 别名
Progressive Myoclonus Epilepsy 8

Emp8

Pme Type 8

Progressive Myoclonic Epilepsy Due To Cers1 Deficiency

Progressive Myoclonus Epilepsy Type 8

Loeffler Syndrome

Loeffler'S Pneumonia

Loffler'S Syndrome

Simple Pulmonary Eosinophilia

Inflammatory Diarrhea
Chemical Colitis
Central Nervous System Tuberculosis

Intracranial Tuberculoma

Tuberculoma Of Brain

Tuberculosis Of Meninges And Central Nervous System

Tuberculous Abscess Of Brain

Tuberculoma, Intracranial

Tuberculosis, Central Nervous System

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis

Enterocolitis Necrotizing

Enterocolitis, Necrotizing

Necrotizing Enterocolitis In Fetus Or Newborn

Perinatal Necrotising Enterocolitis

Pseudomembranous Enterocolitis In Newborn

Nec

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SIGIRR VGNC VGNC:65140
Canis familiaris SIGIRR VGNC VGNC:46167
Mus musculus SIGIRR MGD MGI:1344402
Rattus norvegicus SIGIRR RGD RGD:1306732
Bos taurus SIGIRR VGNC VGNC:34616
Others SIGIRR NCBI