2. Gene
  3. ST8SIA1 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Gene

ST8SIA1 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST8 α-N-乙酰神经氨酸 α-2,8-唾液酸转移酶 1

种属: Homo sapiens

同用名: GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI

基因 ID: 6489 | 基因类型: protein coding

关于 ST8SIA1

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,193,391-22,334,707 (from NCBI)

This gene has 15 transcripts (splice variants), 210 orthologues and 5 paralogues. Broad expression in brain (RPKM 1.5), adrenal (RPKM 0.7) and 19 other tissues.

功能概要

神经节苷脂是含有唾液酸的膜结合糖鞘脂。已知神经节苷脂 GD3 对于培养的恶性细胞的细胞粘附和生长很重要。该基因编码的蛋白质是一种 II 型膜蛋白，可催化唾液酸从 CMP-唾液酸转移到 GM3，产生神经节苷脂 GD3 和 GT3。编码的蛋白质可以在高尔基体中找到，并且是糖基转移酶家族 29 的成员。已经发现该基因的可变剪接转录变体。[RefSeq 提供，2015 年 1 月]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of Glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]

ST8SIA1 基因产物(2)

mRNA Protein Name
NM_001304450.2 NP_001291379.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2
NM_003034.4 NP_003025.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

ST8SIA1 蛋白结构

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (88 - 343)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
蛋白主名 其他名称

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1

ST8SIA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
种属内
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
种属内
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ST8SIA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71334 ST8SIA1 Protein, Human (HEK293, His) Q92185 (Y49-S356) ≥95%

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13856 ST8SIA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ST8SIA1 MGD MGI:106011
Macaca mulatta ST8SIA1 VGNC VGNC:77830
Canis familiaris ST8SIA1 VGNC VGNC:46864
Bos taurus ST8SIA1 VGNC VGNC:49964
Rattus norvegicus ST8SIA1 RGD RGD:3679
Others ST8SIA1 NCBI
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