2. Gene
  3. BMP8B - bone morphogenetic protein 8b Gene

BMP8B - bone morphogenetic protein 8b Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：骨形态发生蛋白 8b

种属: Homo sapiens

同用名: OP2; BMP8

基因 ID: 656 | 基因类型: protein coding

关于 BMP8B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,757,182-39,788,865 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Broad expression in thyroid (RPKM 7.4), adrenal (RPKM 2.8) and 20 other tissues.

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。编码的蛋白质刺激棕色脂肪组织中的产热。该基因的表达可能在胰腺癌中下调。该基因可能源于基因复制事件，其基因副本也存在于 1 号染色体上。[RefSeq 提供，2016 年 7 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic Cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

BMP8B 基因产物(1)

mRNA Protein Name
NM_001720.5 NP_001711.2 bone morphogenetic protein 8B preproprotein

BMP8B 蛋白结构

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (34 - 251)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (299 - 402)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

bone morphogenetic protein 8B

bone morphogenetic protein 8 (osteogenic protein 2)

重组 BMP8B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700032AF Animal-Free BMP-8b Protein, Human (His) P34820 (A264-H402) ≥95%

关联疾病

疾病名称 别名
Pericoronitis

Operculitis
Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder
Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis
Photoallergic Dermatitis

Dermatitis, Photoallergic

Photoallergic Contact Dermatitis

Photoallergic Eczema

Photo-Allergic Contact Eczema
Achondroplasia

Achondroplastic Dwarfism

ACH

Osteosclerosis Congenita

Achondroplastic Physique

Chondrodystrophia

Dwarf, Achondroplastic

Achondroplastic Short Stature

Congenital Osteosclerosis
Granulomatous Endometritis
Breast Giant Fibroadenoma

Giant Fibroadenoma

Giant Fibroadenoma Of Breast
Space Motion Sickness
Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01544 BMP8B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus BMP8B MGD MGI:107335
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