2. Gene
  3. HDAC9 - histone deacetylase 9 Gene

HDAC9 - histone deacetylase 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白脱乙酰酶 9

种属: Rattus norvegicus

同用名: MITR; RGD1310748; RGD1563092

基因 ID: 687001 | 基因类型: protein coding

关于 HDAC9

Primary_assembly 6: 50,763,590-51,625,333 reverse strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 235 orthologues, 12 paralogues and is associated with 4 phenotypes. Biased expression in Spleen (RPKM 53.7), Heart (RPKM 45.8) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括酶结合活性；组蛋白脱乙酰酶活性（H4-K16 特异性）；和转录辅阻遏物活性。参与神经元分化和对苯丙胺的反应。位于核内。大脑中动脉梗死的生物标志物。与人类 HDAC9（组蛋白脱乙酰酶 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including Enzyme binding activity; histone deacetylase activity (H4-K16 specific); and transcription corepressor activity. Involved in neuron differentiation and response to amphetamine. Located in nucleus. Biomarker of middle cerebral artery infarction. Orthologous to human HDAC9 (histone deacetylase 9). [provided by Alliance of Genome Resources, Apr 2022]

HDAC9 基因产物(1)

mRNA Protein Name
NM_001200045.1 NP_001186974.1 histone deacetylase 9
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuron differentiation IEP
IEP: 通过表达模式推断
12850547 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
25452209 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDAC9 蛋白结构

ClassIIa_HDAC9_Gln-rich-N

ClassIIa_HDAC9_Gln-rich-N: cd10163 (58 - 147)

HDAC_classIIa

HDAC_classIIa: cd11681 (658 - 1035)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1094 a.a.
蛋白主名 其他名称

histone deacetylase 9

MEF2-interacting transcriptional repressor

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13322 Pracinostat Inhibitor 99.82% 是
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-14842 Givinostat Inhibitor 98.16% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.28% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 98.84% Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18361 TMP195 Inhibitor 99.57% 否
HY-13428 Tubacin Inhibitor 99.54% 否
HY-18360 TMP269 Inhibitor 98.05% 否
HY-16699 Nexturastat A Inhibitor 98.28% 否
HY-112719 BRD 4354 Inhibitor 99.66% 否
HY-115475 SW-100 Inhibitor 99.59% 否
HY-119939 CHDI-390576 Inhibitor 98.07% 否
HY-149285 NT160 Inhibitor 99.58% 否
HY-112719B BRD 4354 ditrifluoroacetate Inhibitor 98.06% 否
HY-117554 BRD9757 Inhibitor 99.75% 否
HY-146678 HDAC6-IN-5 Inhibitor / 否
HY-146679 HDAC6-IN-6 Inhibitor / 否
HY-150109 Purinostat mesylate Inhibitor / 否
HY-152225 MC2625 Inhibitor / 否
HY-157740 XSJ-10 Inhibitor / 否
HY-149283 JAK/HDAC-IN-2 Inhibitor / 否
HY-152226 MC2590 Inhibitor / 否
HY-169259 HDAC9-IN-1 Inhibitor / 否
HY-149208 HDAC-IN-53 Inhibitor / 否
HY-15144B (S)-Trichostatin A Inhibitor / 否
HY-146684 HDAC-IN-36 Inhibitor / 否
HY-150595 HDAC6-IN-10 Inhibitor / 否
HY-163803 CM-444 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens HDAC9 NCBI NCBI:9734
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